Biological investigation of 131I-labeled new water soluble Ru(II) polypyridyl complex
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New [Ru(L1)(dcbpy)(NCS)2] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)]2, where the ligands (dcbpy=4,4'-dicarboxy-2,2'-bipyridine, L1=dipyrido[3,2-a:2',3'-c]phenazine-11-ylcarbonyl)-sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using 131I-labeled [Ru(L1)(dcbpy)(NCS)2] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen. © 2007 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
131I-labeled ruthenium complex, Charge transfer sensitizer, I-131, Photosensitizers, Polypyridyl complexes, Ruthenium complexes
Kaynak
Applied Radiation and Isotopes
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
66
Sayı
2
