Relative fecal abundance of extended-spectrum-ß-lactamase-producing Escherichia coli strains and their occurrence in urinary tract infections in women

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dc.contributor.authorRuppé E.
dc.contributor.authorLixandru B.
dc.contributor.authorCojocaru R.
dc.contributor.authorBüke Ç.
dc.contributor.authorParamythiotou E.
dc.contributor.authorAngebault C.
dc.contributor.authorVisseaux C.
dc.contributor.authorDjuikoue I.
dc.contributor.authorErdem E.
dc.contributor.authorBurduniuc O.
dc.contributor.authorEl Mniai A.
dc.contributor.authorMarcel C.
dc.contributor.authorPerrier M.
dc.contributor.authorKesteman T.
dc.contributor.authorClermont O.
dc.contributor.authorDenamur E.
dc.contributor.authorArmand-Lefèvre L.
dc.contributor.authorAndremont A.
dc.date.accessioned2019-10-27T08:23:20Z
dc.date.available2019-10-27T08:23:20Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractExtended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL E. coli) strains are of major concern because few antibiotics remain active against these bacteria. We investigated the association between the fecal relative abundance (RA) of ESBL-producing E. coli (ESBL-RA) and the occurrence of ESBL E. coli urinary tract infections (UTIs). The first stool samples passed after suspicion of UTI from 310 women with subsequently confirmed E. coli UTIs were sampled and tested for ESBL-RA by culture on selective agar. Predictive values of ESBL-RA for ESBL E. coli UTI were analyzed for women who were not exposed to antibiotics when the stool was passed. ESBL E. coli isolates were characterized for ESBL type, phylogroup, relatedness, and virulence factors. The prevalence of ESBL E. coli fecal carriage was 20.3%, with ESBL E. coli UTIs being present in 12.3% of the women. The mean ESBL-RA (95% confidence interval [CI]) was 13-fold higher in women exposed to antibiotics at the time of sampling than in those not exposed (14.3% [range, 5.6% to 36.9%] versus 1.1% [range, 0.32% to 3.6%], respectively; P<0.001) and 18-fold higher in women with ESBL E. coli UTI than in those with another E. coli UTI (10.0% [range, 0.54% to 100%] versus 0.56% [range, 0.15% to 2.1%[, respectively; P<0.05). An ESBL-RA of<0.1% was 100% predictive of a non-ESBL E. coli UTI. ESBL type, phylogroup, relatedness, and virulence factors were not found to be associated with ESBL-RA. In conclusion, ESBL-RA was linked to the occurrence of ESBL E. coli UTI in women who were not exposed to antibiotics and who had the same clone of E. coli in urine samples and fecal samples. Especially, a low ESBL-RA appeared to be associated with a low risk of ESBL E. coli infection. Copyright © 2013, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.doi10.1128/AAC.00238-13en_US
dc.identifier.endpage4517en_US
dc.identifier.issn0066-4804
dc.identifier.issue9en_US
dc.identifier.pmid23836184en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4512en_US
dc.identifier.urihttps://doi.org/10.1128/AAC.00238-13
dc.identifier.urihttps://hdl.handle.net/11454/26411
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleRelative fecal abundance of extended-spectrum-ß-lactamase-producing Escherichia coli strains and their occurrence in urinary tract infections in womenen_US
dc.typeArticleen_US

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