Pharmacoinformatics approaches in the discovery of drug-like antimicrobials of plant origin

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dc.contributor.authorKhan, Duaa Ahmad
dc.contributor.authorHamdani, Syed Damin Abbas
dc.contributor.authorIftikhar, Sahar
dc.contributor.authorMalik, Sohaib Zafar
dc.contributor.authorZaidi, Najam-us-Sahar Sadaf
dc.contributor.authorGul, Alvina
dc.contributor.authorGonenc, Tuba
dc.date.accessioned2021-05-03T20:27:44Z
dc.date.available2021-05-03T20:27:44Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractMedicinal plants have served as an important source for addressing the ailments of humans and animals alike. The emergence of advanced technologies in the field of drug discovery and development has helped in isolating various bioactive phytochemicals and developing them as drugs. Owing to their significant pharmacological benefits and minimum adverse effects, they not only serve as good candidates for therapeutics themselves but also help in the identification and development of related drug like molecules against various metabolic and infectious diseases. The ever-increasing diversity, severity and incidence of infectious diseases has resulted in an exaggerated mortality and morbidity levels. Geno-proteomic mutations in microbes, irrational prescribing of antibiotics, antimicrobial resistance and human population explosion, all call for continuous efforts to discover and develop alternated therapeutic options against the microbes. This review article describes the pharmacoinformatics tools and methods which are currently used in the discovery of bioactive phytochemicals, thus making the process more efficient and effective. The pharmacological aspects of the drug discovery and development process have also been reviewed with reference to the in silico activities. Communicated by Ramaswamy H. Sarmaen_US
dc.identifier.doi10.1080/07391102.2021.1894982en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.pmid33663347en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2021.1894982
dc.identifier.urihttps://hdl.handle.net/11454/69631
dc.identifier.wosWOS:000625670500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial discoveryen_US
dc.subjecthigh-throughput screeningen_US
dc.subjectmedicinal plantsen_US
dc.subjectpharmacoinformaticsen_US
dc.subjectphytochemicalsen_US
dc.titlePharmacoinformatics approaches in the discovery of drug-like antimicrobials of plant originen_US
dc.typeArticleen_US

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