Fc gamma RIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis

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dc.contributor.authorZeyrek, Dost
dc.contributor.authorTanac, Remziye
dc.contributor.authorAltinoz, Serdar
dc.contributor.authorBerdeli, Afig
dc.contributor.authorGulen, Figen
dc.contributor.authorKoksoy, Huseyin
dc.contributor.authorDemir, Esen
dc.date.accessioned2019-10-27T19:55:44Z
dc.date.available2019-10-27T19:55:44Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractFc receptors (FcR) play an important role in immune regulation. This might be linked to the variability in immune response, therefore relating to the pathogenesis of atopic diseases. The aim of the present study was to evaluate the Fc gamma RIIIa gene polymorphism in Turkish children with asthma and allergic rhinitis. The study included 364 atopic children (184 bronchial asthma, 180 allergic rhinitis) and 234 healthy subjects as the control group, aged between 5 to 16 years. Patients were recruited from outpatient clinics of allergy and general pediatric care. Plasma IgE concentrations were measured by immunoassays and skin prick test was done in children with atopic diseases. The Fc gamma RIIIa gene polymorphism was determined using the polymerase chain reaction method. Distribution of V158V genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 5.33, 95% CI: 2.80-10.23, p < 0.001; for allergic rhinitis OR: 3.25, 95% CI: 1.75-6.07, p = 0.001). Distribution of 158 V allele was significantly different among asthmatic children (OR: 2.20, 95% CI: 1.65-2.92, p < 0.001) and allergic rhinitis patients (OR: 1.77, 95% CI: 1.32-2.35, p < 0.001) compared to healthy controls. Our study shows that the V158V genotype in Fc gamma RIIIa gene polymorphism may be a genetic risk factor for the development of atopic diseases.en_US
dc.identifier.doi10.1111/j.1399-3038.2007.00553.xen_US
dc.identifier.endpage24en_US
dc.identifier.issn0905-6157
dc.identifier.issue1en_US
dc.identifier.pmid18199088en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1111/j.1399-3038.2007.00553.x
dc.identifier.urihttps://hdl.handle.net/11454/40726
dc.identifier.volume19en_US
dc.identifier.wosWOS:000252329700004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofPediatric Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFcR gamma IIIa gene polymorphismen_US
dc.subjectbronchial asthmaen_US
dc.subjectallergic rhinitisen_US
dc.subjectchildrenen_US
dc.titleFc gamma RIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitisen_US
dc.typeArticleen_US

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