Taurine supplementation protects lens against glutathione depletion

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dc.authorscopusid8970943500
dc.authorscopusid6508120465
dc.authorscopusid57226065401
dc.authorscopusid11141742600
dc.contributor.authorSevin, G.
dc.contributor.authorKerry, Z.
dc.contributor.authorSozer, N.
dc.contributor.authorOzsarlak-Sozer, G.
dc.date.accessioned2023-01-12T20:12:27Z
dc.date.available2023-01-12T20:12:27Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractOBJECTIVE: Cataract which is defined as opacification of eye lens forms approximately 40% of total blindness causes all through the world. Age is the biggest risk factor for cataracts and oxidative stress is known to be one of the most important factors causing cataract formation. Age-related nuclear cataract (ARN) is associated with a loss of glutathione in the center of the lens. Taurine is an important antioxidant in lens tissue. Although, there is a high amount of taurine in lenses in early life, its concentration declines with age. In this study, we aimed to investigate the effects of supplemental taurine in lens tissues in an in vivo oxidative stress model which is induced by glutathione depletion to mimic ARN. MATERIALS AND METHODS: Glutathione depletion was induced in rabbits subcutaneously with l-Buthionine -(S,R)-sulfoximine (BSO)- a glutathione inhibitor and the rabbits were treated with taurine. Total GSH, reduced GSH, GSH/GSSG ratio and MDA levels were measured. RESULTS: BSO lowered the reduced GSH and total GSH levels and GSH/GSSG ratio. Taurine reversed these effects. On the other hand, BSO enhanced MDA level which is normalized by taurine. CONCLUSIONS: These findings suggest that glutathione depletion with BSO may be a useful model to mimic ARN and dietary intake of taurine, may have an important role in decelerating the process of cataract formation.en_US
dc.description.sponsorshipEge University Scientific Research Fund [08ECZ014]en_US
dc.description.sponsorshipWe are thankful to Dokuz Eylul University Medical School, Learning Resources Center Research Laboratory and Dr. Memduh Bulbul for technical support with HPLC measurements. This study was supported by a grant from the Ege University Scientific Research Fund (08ECZ014 to G Ozsarlak-Sozer).en_US
dc.identifier.doi10.26355/eurrev_202107_26244
dc.identifier.endpage4526en_US
dc.identifier.issn1128-3602
dc.identifier.issue13en_US
dc.identifier.pmid34286494en_US
dc.identifier.scopus2-s2.0-85110321655en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4520en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202107_26244
dc.identifier.urihttps://hdl.handle.net/11454/78306
dc.identifier.volume25en_US
dc.identifier.wosWOS:000675312600014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathioneen_US
dc.subjectLensen_US
dc.subjectBSOen_US
dc.subjectTaurineen_US
dc.subjectCataracten_US
dc.subjectOxidative stressen_US
dc.subjectOxidative Stressen_US
dc.subjectRat Lensen_US
dc.subjectFluorescence Detectionen_US
dc.subjectCataracten_US
dc.subjectBiosynthesisen_US
dc.subjectExpressionen_US
dc.subjectProteinsen_US
dc.subjectDamageen_US
dc.subjectCellsen_US
dc.titleTaurine supplementation protects lens against glutathione depletionen_US
dc.typeArticleen_US

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