The difference in lactate dehydrogenase activity between pre- and post-mobilization periods is a good indicator of successful stem cell mobilization

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dc.contributor.authorDonmez, Ayhan
dc.contributor.authorKabaroglu, Ceyda
dc.contributor.authorGokmen, Nihal
dc.contributor.authorTombuloglu, Murat
dc.date.accessioned2019-10-27T21:53:06Z
dc.date.available2019-10-27T21:53:06Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractPredicting poor stem cell mobilization may prevent the costs and complications associated with remobilization. We retrospectively reviewed the relationship between serum lactate dehydrogenase (sLDH) activity and peripheral blood CD34 (PBCD34) cell counts in 46 granulocyte colony stimulating factor (G-CSF) induced mobilization cycles with or without chemotherapy. A significant correlation between post-mobilization (pre-apheresis) sLDH activity and PBCD34 count was found (r(s) = 0.43, p = 0.007). A strong correlation was shown between the pre- and post-mobilization sLDH activity difference and PBCD34 count (r(s) = 0.55, p = 0.001). With respect to sLDH activity differences; (a) all patients with a difference of >300 U/L, (b) 71% of patients with a difference of 100-300 U/L, and (c) 44% of patients with a difference of <100 U/L were considered to have good mobilizations. The sLDH activity difference between pre- and post-mobilization is a good indicator of successful mobilization. According to our results, the success of mobilization can be predicted based on sLDH activity differences; (i) good mobilization if the difference is >300 U/L, (ii) intermediate risk if the difference is 100-300 U/L, and (iii) high risk if the difference is <100 U/L. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2012.05.019en_US
dc.identifier.endpage86en_US
dc.identifier.issn1473-0502
dc.identifier.issue1en_US
dc.identifier.pmid22709439en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2012.05.019
dc.identifier.urihttps://hdl.handle.net/11454/47819
dc.identifier.volume48en_US
dc.identifier.wosWOS:000316646900015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLactate dehydrogenaseen_US
dc.subjectRisk factoren_US
dc.subjectStem cell mobilizationen_US
dc.titleThe difference in lactate dehydrogenase activity between pre- and post-mobilization periods is a good indicator of successful stem cell mobilizationen_US
dc.typeArticleen_US

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