Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population

Basit Öğe Kaydı
dc.contributor.authorBerdeli A.
dc.contributor.authorSekuri C.
dc.contributor.authorSirri Cam F.
dc.contributor.authorErcan E.
dc.contributor.authorSagcan A.
dc.contributor.authorTengiz I.
dc.contributor.authorEser E.
dc.contributor.authorAkin M.
dc.date.accessioned2019-10-27T00:12:09Z
dc.date.available2019-10-27T00:12:09Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe renin-angiotensin system (RAS) and endothelial nitric oxide (NO) affect the pathogenesis of atherosclerosis and prognosis of coronary artery disease (CAD). Previous epidemiologic data suggested that genetic factors are more likely to affect young rather than old people. Our objective was to investigate the association between the polymorphisms of eNOS (Glu298Asp) and the RAS genes and premature CAD in a Turkish population. A total of 115 Turkish patients with premature CAD and 83 controls were included in the study. ACE I/D, AT1R A/C, AGT T/M and eNOS Glu298Asp gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). It was found that increased premature CAD risk is associated with higher frequencies of the ACE DD [OR: 2.600 (CI 95% 1.395-4.847, p=0.002)], AGT MM [OR=2.407 (CI 95% 1.267-4.573, p=0.007)] and eNOS 894TT [OR=17.000 (CI 95% 3.952-73.125, p<0.001)] genotypes. Carriers of ACE DD+eNOS 894TT (p=0.002), AGT MM+eNOS 894TT (p=0.001), AT1R AA+eNOS 894TT and AT1R non-AA+eNOS 894TT (p=0.002) genotypes were significantly associated with the risk of premature CAD. This study indicates a synergistic contribution of RAS genes (ACE I/D, AGT T/M, AT1R T/C) and eNOS Glu298Asp polymorphisms to the development of the premature CAD. © 2004 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.cccn.2004.08.015en_US
dc.identifier.endpage94en_US
dc.identifier.issn0009-8981
dc.identifier.issue01.Feben_US
dc.identifier.pmid15563875en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1016/j.cccn.2004.08.015
dc.identifier.urihttps://hdl.handle.net/11454/22289
dc.identifier.volume351en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial nitric oxide synthaseen_US
dc.subjectGene polymorphismen_US
dc.subjectPremature coronary artery diseaseen_US
dc.subjectRenin-angiotensin systemen_US
dc.titleAssociation between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish populationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu