Long-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experience

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dc.contributor.authorBulut, I. K.
dc.contributor.authorTaner, S.
dc.contributor.authorKeskinoglu, A.
dc.contributor.authorToz, H.
dc.contributor.authorSarsik, B.
dc.contributor.authorSezer, T. O.
dc.contributor.authorKabasakal, C.
dc.date.accessioned2020-12-01T12:09:37Z
dc.date.available2020-12-01T12:09:37Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description12th Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA) -- OCT 18-21, 2018 -- Trabzon, TURKEYen_US
dc.descriptionTaner, Sevgin/0000-0003-1578-789Xen_US
dc.description.abstractIntroduction and Aim. Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage renal disease in children. We analyzed the long-term outcome of pediatric patients with FSGS undergoing renal transplantation. the objective of the study is to report the experience of a single center and determine the incidence of recurrence, rejection, graft loss, and related risk factors. Materials and Method. This retrospective cohort study was performed between 1991 and 2018. Thirty patients with a pathologic diagnosis of primary FSGS were included in the study. the patients were diagnosed with FSGS according to histologic features in biopsies. Results. Twenty-one of the donors were deceased (70%) and 9 were alive (30%). FSGS recurred in only 2 patients. Graft loss occurred in 6 patients (20%). the causes of graft loss were chronic rejection in 4 patients and acute rejection in 2. Our graft survival rate was 100% at 1 year, 91% at 5 years, 80% at 10 years, 70% at 15 years, and 42% at 20 years. Five- and 10-year graft survival rates were 83% and 83% in living donors and 94% and 79% in deceased donors, respectively. According to Kaplan-Meier analysis, there was no statistically significant difference in terms of graft survival between living and deceased donors. Conclusion. This study, with its contribution to literature in terms of long follow-up of FSGS patients from childhood to adulthood, is important. However, further studies are required.en_US
dc.description.sponsorshipTurkish Transplantat Ctr Coordinat Assocen_US
dc.identifier.doi10.1016/j.transproceed.2019.01.096en_US
dc.identifier.endpage1069en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue4en_US
dc.identifier.pmid31101172en_US
dc.identifier.startpage1064en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2019.01.096
dc.identifier.urihttps://hdl.handle.net/11454/63515
dc.identifier.volume51en_US
dc.identifier.wosWOS:000500179300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLong-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experienceen_US
dc.typeConference Objecten_US

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