Assessment of chemotherapy-induced changes in bone sarcomas clinical experience with 99tcm-mdp three-phase dynamic bone scintigraphy

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dc.contributor.authorÖZcan Z.
dc.contributor.authorBurak Z.
dc.contributor.authorKumanliogklu K.
dc.contributor.authorÖZkilicc H.
dc.contributor.authorSabah D.
dc.contributor.authorBascdemir G.
dc.contributor.authorBilkay B.
dc.contributor.authorCcetingul N.
dc.date.accessioned2019-10-27T00:27:15Z
dc.date.available2019-10-27T00:27:15Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the value of three-phase dynamic bone scintigraphy (TPBS) in the assessment of the response of bone sarcomas to pre-operative chemotherapy and to correlate serial scintigraphic changes with histological findings. The study group comprised 27 patients (osteogenic sarcoma, n = 20; Ewing's sarcoma, n = 5; malignant fibrous histiocytoma, n = 2) with a mean age of 19.2 years. All patients received 99Tcm-methylene diphosphonate TPBS before and after pre-operative chemotherapy. Each phase of the imaging procedure was interpreted qualitatively and quantitatively. The percentage of tumour necrosis was analysed on resection materials following surgery. Histologically, 12 patients were non-responsive (tumour necrosis less than 90%) and 15 patients were responsive (tumour necrosis more than 90%). A decrease in the tumour blood flow ratio and extension were the most notable findings in the responders. The mean change in the tumour blood flow ratio following therapy was 58.7 ± 8.3% and 19.9 ± 26.6% (P < 0.005) in responders and non-responders respectively. The accuracy of three-phase imaging and static bone scintigraphy was 88% and 74% respectively. Since bone scintigraphy is a valuable technique owing to its ability to detect distant metastases in clinically early disease, TPBS should be helpful in monitoring therapy effects without any additional cost or radiation dose. © 1998 Lippincott-Raven Publishers.en_US
dc.identifier.doi10.1080/00006231-199901000-00008en_US
dc.identifier.endpage48en_US
dc.identifier.issn0143-3636
dc.identifier.issue1en_US
dc.identifier.pmid9949412en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1080/00006231-199901000-00008
dc.identifier.urihttps://hdl.handle.net/11454/23503
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssessment of chemotherapy-induced changes in bone sarcomas clinical experience with 99tcm-mdp three-phase dynamic bone scintigraphyen_US
dc.typeArticleen_US

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