Frequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway disease

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dc.contributor.authorYuksel, H
dc.contributor.authorYilmaz, O
dc.contributor.authorKirmaz, C
dc.contributor.authorAydogdu, S
dc.contributor.authorKasirga, E
dc.date.accessioned2019-10-27T19:19:41Z
dc.date.available2019-10-27T19:19:41Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractGastroesophageal reflux disease (GERD) is commonly associated with asthma; however, frequency in nonatopic children with asthmatic symptoms is unknown. The aim of this study was to determine the frequency of gastroesophageal reflux (GER) in nonatopic children with asthma-like airway disease that recur despite conventional asthma treatment and to evaluate the clinical response to lansoprazole treatment. Twent-five nonatopic children aged between 1 and 16 years who have asthma-like airway disease and 25 healthy children were included in the study. All cases underwent 24h pH monitoring with dual. sensor catheters. Additionally, acid suppressor treatment was administered to patients diagnosed as having GERD and clinical response was evaluated. Major symptoms encountered in the patient group included wheezing and cough (88%, and 32%, respectively). Reflux episodes were more common in distal esophagus during the prone position (reflux index (RI) of 11.5 +/- 10.3 vs. 16.2 +/- 9.4 during supine vs. prone). ALL distal esophageal parameters were significantly higher in the patient group except number of reflux episodes lasting longer than 5 min (RI of 13.3 +/- 13.1 vs. 3.9 +/- 2.9 in the patient vs. control groups, respectively). There was a significant improvement in symptoms and requirement for medication with treatment (number of systems decreased from 2.3 +/- 0.6 to 0.4 +/- 0.6, P = 0.00). In conclusion, GERD is significantly more common in nonatopic children with asthma-Like airway disease compared to the controls and clinical improvement is significant after acid suppressor treatment. Thus, we suggest that children followed-up with the diagnosis of nonatopic asthma with recurrent exacerbations despite adequate asthma treatment have a high frequency of GER and that Lansoprazole treatment may be considered early in management. (c) 2005 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rmed.2005.07.006en_US
dc.identifier.endpage398en_US
dc.identifier.issn0954-6111
dc.identifier.issn1532-3064
dc.identifier.issue3en_US
dc.identifier.pmid16099150en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2005.07.006
dc.identifier.urihttps://hdl.handle.net/11454/38778
dc.identifier.volume100en_US
dc.identifier.wosWOS:000235862800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgastroesophageal reflux diseaseen_US
dc.subjectnonatopic asthmaen_US
dc.subjectpH monitoringen_US
dc.subjectlansoprazoleen_US
dc.titleFrequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway diseaseen_US
dc.typeArticleen_US

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