Yeasts in apical periodontitis

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dc.contributor.authorWaltimo, TMT
dc.contributor.authorSen, BH
dc.contributor.authorMeurman, JH
dc.contributor.authorOrstavik, D
dc.contributor.authorHaapasalo, MPP
dc.date.accessioned2019-10-27T18:40:26Z
dc.date.available2019-10-27T18:40:26Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractMicrobiological reports of apical periodontitis have revealed that yeasts can be isolated from approximately 5-20% of infected root canals. They occur either in pure cultures or together with bacteria. Almost all isolated yeasts belong to the genus Candida, and the predominant species is C. albicans. Pheno- and genotypic profiles of C. albicans isolates show heterogeneity comparable with those of isolates from other oral sites. C. albicans expresses several virulence factors that are capable of infecting the dentin-pulp complex, including dentinal tubules. This causes, consequentially, an inflammatory response around the root apex, which suggests a pathogenic role for this organism in apical periodontitis. Yeasts are particularly associated with persistent root canal infections that do not respond favorably to conservative root canal therapy. This may be due to the resistance of all oral Candida species against a commonly used topical medicament, calcium hydroxide. However, other antimicrobial agents may offer alternative therapeutic approaches and improve the treatment of these persistent cases of apical periodontitis.en_US
dc.identifier.doi10.1177/154411130301400206en_US
dc.identifier.endpage137en_US
dc.identifier.issn1045-4411
dc.identifier.issue2en_US
dc.identifier.pmid12764075en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.1177/154411130301400206
dc.identifier.urihttps://hdl.handle.net/11454/36903
dc.identifier.volume14en_US
dc.identifier.wosWOS:000226594700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Amer Assoc Dental Researchi A D R/A A D Ren_US
dc.relation.ispartofCritical Reviews in Oral Biology & Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapical periodontitisen_US
dc.subjectCandidaen_US
dc.subjectendodonticsen_US
dc.subjectyeast infectionen_US
dc.titleYeasts in apical periodontitisen_US
dc.typeReview Articleen_US

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