Prolonged skin retention of clobetasol propionate by bio-based microemulsions: a potential tool for scalp psoriasis treatment

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dc.contributor.authorLangasco, Rita
dc.contributor.authorTanriverdi, Sakine Tuncay
dc.contributor.authorOzer, Ozgen
dc.contributor.authorRoldo, Marta
dc.contributor.authorCossu, Massimo
dc.contributor.authorRassu, Giovanna
dc.contributor.authorGiunchedi, Paolo
dc.contributor.authorGavini, Elisabetta
dc.date.accessioned2019-10-27T10:46:45Z
dc.date.available2019-10-27T10:46:45Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractNovel effective and cosmetically acceptable formulations are needed for the treatment of scalp psoriasis, due to the poor efficacy of the current products. The challenge in developing safe, efficient, and convenient delivery systems for this drug was addressed in the present work by formulating clobetasol propionate-loaded W/O microemulsions (MEs). Pseudo-ternary phase diagrams were constructed by using a combination of biocompatible and biodegradable excipients. Characterization studies demonstrated that selected MEs had suitable technological features such as being Newtonian fluids, possessing low viscosity, and high thermodynamic stability. Photomicrographs showed a significant alteration of the skin structure after treatment with MEs, and a preferential concentration of these in the stratum corneum and epidermis. These data, together with ex vivo permeation results, suggested an enhanced topical targeted effect due to an increased drug retention efficacy in the upper skin layers, as desired. Moreover, the bio-based excipients selected could contribute to the healing of the psoriatic scalp. In this way, the improvement of clobetasol efficacy is combined with the useful properties of the microemulsion components and with environmental safety.en_US
dc.description.sponsorshipSardinia Regional Government (P.O.R. Sardegna F.SE Operational Programme of the Autonomous Region of Sardinia); Sardinia Regional Government (European Social Fund)en_US
dc.description.sponsorshipDr. Rita Langasco gratefully acknowledges Sardinia Regional Government for the financial support of her PhD scholarship (P.O.R. Sardegna F.SE Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007-2013 - Axis IV Human Resources, Objective l0.3, Line of Activity l.3.1.). The authors thank Mr. Phil Warren for the help in the interpretation of the histological data. The authors would also like to thank Ege University, Faculty of Pharmacy, Pharmaceutical Sciences Research Centre (FABAL) for rheology facilities and, particularly, Dr. Mehmet Ali (Ege University, Faculty of Pharmacy and Department of Pharmaceutical Technology) for giving permission to use pseudoternary phase diagram program.en_US
dc.identifier.doi10.1080/03639045.2017.1395458en_US
dc.identifier.endpage406en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue3en_US
dc.identifier.pmid29098874en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage398en_US
dc.identifier.urihttps://doi.org/10.1080/03639045.2017.1395458
dc.identifier.urihttps://hdl.handle.net/11454/31341
dc.identifier.volume44en_US
dc.identifier.wosWOS:000423490100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicroemulsionen_US
dc.subjectcorticosteroiden_US
dc.subjectbiocompatible formulationen_US
dc.subjecttopical deliveryen_US
dc.subjectscalp psoriasisen_US
dc.titleProlonged skin retention of clobetasol propionate by bio-based microemulsions: a potential tool for scalp psoriasis treatmenten_US
dc.typeArticleen_US

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