Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson's disease

Basit Öğe Kaydı
dc.contributor.authorHasanov, Samir
dc.contributor.authorBiler, Elif Demirkilinc
dc.contributor.authorAcarer, Ahmet
dc.contributor.authorAkkin, Cezmi
dc.contributor.authorColakoglu, Zafer
dc.contributor.authorUretmen, Onder
dc.date.accessioned2019-10-27T09:44:01Z
dc.date.available2019-10-27T09:44:01Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionMeeting of the Turkish-Ophthalmology-Society -- 2016 -- Antalya, TURKEYen_US
dc.description.abstractPurposeTo evaluate and follow-up of functional and morphological changes of the optic nerve and ocular structures prospectively in patients with early-stage Parkinson's disease.Materials and methodsNineteen patients with a diagnosis of early-stage Parkinson's disease and 19 age-matched healthy controls were included in the study. All participants were examined minimum three times at the intervals of at least 6month following initial examination. Pattern visually evoked potentials (VEP), contrast sensitivity assessments at photopic conditions, color vision tests with Ishihara cards and full-field visual field tests were performed in addition to measurement of retinal nerve fiber layer (RNFL) thickness of four quadrants (top, bottom, nasal, temporal), central and mean macular thickness and macular volumes.ResultsBest corrected visual acuity was observed significantly lower in study group within all three examinations. Contrast sensitivity values of the patient group were significantly lower in all spatial frequencies. P100 wave latency of VEP was significantly longer, and amplitude was lower in patient group; however, significant deterioration was not observed during the follow-up. Although average peripapillary RNFL thickness was not significant between groups, RNFL thickness in the upper quadrant was thinner in the patient group. While there was no difference in terms of mean macular thickness and total macular volume values between the groups initially, a significant decrease occurred in the patient group during the follow-up. During the initial and follow-up process, a significant deterioration in visual field was observed in the patient group.ConclusionStructural and functional disorders shown as electro-physiologically and morphologically exist in different parts of visual pathways in early-stage Parkinson's disease.en_US
dc.description.sponsorshipTurkish Ophthalmol Socen_US
dc.identifier.doi10.1007/s10792-018-0934-yen_US
dc.identifier.endpage1262en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue6en_US
dc.identifier.pmid29744762en_US
dc.identifier.startpage1255en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-018-0934-y
dc.identifier.urihttps://hdl.handle.net/11454/28946
dc.identifier.volume39en_US
dc.identifier.wosWOS:000469888700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson's diseaseen_US
dc.subjectContrast sensitivityen_US
dc.subjectColor visionen_US
dc.subjectVisual field analysisen_US
dc.subjectVEPen_US
dc.subjectOCTen_US
dc.subjectRNFL thicknessen_US
dc.subjectMacular thicknessen_US
dc.subjectMacular volumeen_US
dc.titleFunctional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson's diseaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu