Gingival crevicular fluid Bax, Bcl-xl, interleukin-22, and transforming growth factor beta 1 levels in stage III periodontitis

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dc.authorid0000-0002-5238-9738
dc.authorid0000-0003-2581-1400
dc.authorid0009-0004-6479-3297
dc.authorid0000-0002-4869-9629
dc.contributor.authorAfacan, Beral
dc.contributor.authorBudak, Utkucan
dc.contributor.authorAltinyurek, Ece Erdem
dc.contributor.authorOzden, Can
dc.contributor.authorCevik, Ozge
dc.contributor.authorKose, Timur
dc.contributor.authorEmingil, Gulnur
dc.date.accessioned2025-02-17T13:34:18Z
dc.date.available2025-02-17T13:34:18Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractBackground Intrinsic apoptosis plays a critical role in immune defense and inflammation. Its dysregulation is involved in various chronic diseases. The B-cell lymphoma 2 (Bcl-2) family primarily mediates this mitochondrial pathway. This study aimed to investigate the proapoptotic Bcl-2-associated X protein (Bax) and antiapoptotic B-cell lymphoma-extra large (Bcl-xl) levels and their association with interleukin-22 (IL-22) and transforming growth factor beta 1 (TGF-beta 1) in the gingival crevicular fluid (GCF) of patients with periodontitis. Methods A total of 75 systemically healthy nonsmokers were enrolled, of whom 23 had stage III periodontitis, 26 had gingivitis, and 26 were periodontally healthy. Whole-mouth clinical periodontal measurements were recorded. Bax, Bcl-xl, IL-22, and TGF-beta 1 levels in the GCF were determined by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using nonparametric statistical tests. Results The periodontitis group had significantly lower GCF Bax levels than the gingivitis group (p < 0.05). The periodontitis and gingivitis groups had higher GCF Bcl-xl levels than the periodontally healthy group (p < 0.05). GCF IL-22 levels were similar in all groups (p > 0.05). The periodontitis group had lower GCF TGF-beta 1 levels than the gingivitis and periodontally healthy groups (p < 0.05). The diseased groups had a lower GCF Bax/Bcl-xl ratio than the healthy controls (p < 0.05). IL-22 was positively correlated with Bax (p < 0.05). Conclusions This is the first study investigating GCF Bax and Bcl-xl levels in periodontal health and disease. Increased GCF Bcl-xl levels and a decreased Bax/Bcl-xl ratio in stage III periodontitis implicate that those apoptotic proteins may be involved in the pathogenesis of periodontal disease. Further studies are needed to enlighten the possible role of Bax and Bcl-xl and their association with IL-22 and TGF-beta 1 in periodontal diseases.
dc.identifier.citationAfacan, B., Budak, U., Altinyurek, E. E., Ozden, C., Cevik, O., Kose, T., & Emingil, G. (2024). Gingival crevicular fluid bax, bcl-xl, interleukin-22, and transforming growth factor beta 1 levels in stage III periodontitis. Journal of Periodontology (1970)
dc.identifier.doi10.1002/JPER.24-0356
dc.identifier.endpage10
dc.identifier.issn0022-3492
dc.identifier.issueDec
dc.identifier.pmid39692450
dc.identifier.scopus2-s2.0-85212521313
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/JPER.24-0356
dc.identifier.urihttps://hdl.handle.net/11454/116071
dc.identifier.wosWOS:001380614600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKose, Timur
dc.institutionauthorid0000-0002-5238-9738
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapoptosis
dc.subjectcytokine(s)
dc.subjectgingival crevicular fluid
dc.subjectgingivitis
dc.subjectperiodontitis
dc.titleGingival crevicular fluid Bax, Bcl-xl, interleukin-22, and transforming growth factor beta 1 levels in stage III periodontitis
dc.typeArticle

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