Synthesis of novel pyrimidine-based Schiff base complexes: Targeting Amyloid-(3 aggregation in Alzheimer's disease
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Inc Elsevier Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A novel Schiff base with imine/amine donors, 5-((3,3-diphenylalilidene)amino)pyrimidine-4-amine (L), and its new Platinum(II) and Ruthenium(II) complexes (I and II) were synthesized and characterized using FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analyses. The ability of these complexes to inhibit amyloid beta (A(31_42) aggregation was evaluated using the human neuroblastoma cell line (SH-SY5Y). The complexes effectively inhibited A(31_42 aggregation at a 1:1 M ratio. Both complexes increased cell viability up to 80 % at concentrations of 10 mu M. At this concentration, the cell viability value found by A(31_42 aggregation is around 65 %. Aggregation kinetics were fluorometrically monitored using Thioflavin T. These findings were further supported by scanning electron microscopy and transmission electron microscopy. In addition, the interaction of the complexes with A(31_16 was investigated using MALDI-TOF/MS and 1H NMR spectroscopy. All findings showed that A(31_42 in both complexes is active in the inhibition of amyloid aggregation.
Açıklama
Anahtar Kelimeler
Amyloid beta (Aβ), Anti-Alzheimer's activity, Aβ aggregation, Schiff base, Schiff base–platinum complexes, Schiff base–ruthenium complexes, SH-SY5Y neuroblastoma cells
Kaynak
Bioorganic Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
154
Sayı
Dec
Künye
Irisli, S., Cakir, A., & Gunnaz, S. (2025). Synthesis of novel pyrimidine-based schiff base complexes: Targeting amyloid-(3 aggregation in alzheimer's disease. Bioorganic Chemistry, 154
