Yüksek mikst antiglobulin reaksiyon değerinin infertil erkek hastaların tedavisinde kullanılan yardımcı üreme yöntemlerinin başarısı üzerine etkisi
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, Anlamlı yüksek mikst antiglobulin reaksiyon (MAR) değeri olan infertil erkek hastalardaki uygulanmış yardımcı üreme yöntemlerin (YÜY) sonuçlarının retrospektif analizini değerlendirmeyi amaçladık. Çalışma kapsamında 1995-2005 tarihleri arasında Ege Üniversitesi Aile Planlanması ve Kısırlık Araştırılma (Tüp Bebek) Merkezi’nde infertilite nedeniyle değerlendirilen yüksek MAR değerine sahip 69 infertil erkek hasta incelenmiştir. Hastaların tamamına çeşitli YÜY (İUİ, İVF, İCSİ) uygulanmıştır. Yüksek MAR düzeyinin YÜY’e olan etkisi analiz edilmiştir. Çalışmamıza alınan hastaların ortalama yaşı 35.5±3.9. Ortalama MAR değerleri %84±0.2. YÜY’den toplam 65 İUİ, 18 İCSİ ve 4 İVF uygulanmıştır. 21 hasta (%30.4) YÜY öncesi 3 ay süreyle kortikosteroid almışlardı. YÜY uygulanan 5 hastada İUİ (başarı: %6.1), 9 hastada İCSİ (başarı: %50) ve 1 hastada İVF (başarı: %25) sonucunda toplam 15 çiftte gebelik elde edilebilmişti. Bunlardan sadece altısı (%40) işlem öncesi kortikosteroid tedavisi almıştır, kortikoterapi alan hastaların sadece %28.5’ini oluşturuyordu. Gebelik oluşan çiftlerden %53.3’ünde erkek eş sigara kullanmaktayken, gebelik oluşmayan grupta sigara içme oranı %80 idi (p<0.05). YÜY öncesi kortikosteroid tedavisi kullanılmasının YÜY sonuçlarını etkilemediği tespit edilmiştir (p>0.05). Yüksek MAR değeri olan hastalarda YÜY ile %22’ye varan gebelik oranlarına ulaşmak mümkün olmaktadır. YÜY öncesi kortikosteroid tedavisinin YÜY’ine olumlu bir etkisi görülmemektedir ve bu hastalara direkt İCSİ uygulanması önerilir. Sigara kullanımının YÜY’ine olumsuz etkisi vardır.
Introduction: Retrospective analysis of the results of assisted reproductive techniques (ART) of infertile males with high mixed anti-globulin reactions (MAR). Materials and Methods: Data of 69 infertile male patients with high mixed anti-globulin reactions values (>15%) treated in Ege University IVF Centre between 1997 and 2005 were retrospectively evaluated. Various assisted reproductive techniques (ART): Intrauterine inseminations (IUI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) were applied to all patients. The influences of high MAR values on ART were analyzed. Patients were also categorized with regards to smoking and receiving corticotherapy before treatment. SPSS 13.0 for Windows XP were used for statistical analysis. Results: Mean patients age was 35.5±3.9 years old. Mean MAR value was 84±0.2%. A total of 87 ART were applied (65 IUI, 18 ICSI and 4 IVF). Out of 69 patients 21 (30.4%) of them received corticosteroids before any ART for 3 months. ART were successful in 15 infertile couples: 5 IUI (success: 6.1%); 9 ICSI (success: 50%); 1 IVF (success: 25%) and unsuccessful in 54 infertile couples. We had 15 successful ART and only 6 of them (42.86%) were instructed corticotherapy before ART and this constituted 28.5% of patients receiving corticotherapy. We had 15 successful and 54 unsuccessful ART cycles out of 69 couples. Male partner had an anamnesis about smoking at 53% and 80% of couples with successful and unsuccessful ART cycles respectively and the difference was statistically significant (p<0.05). Corticotherapy did not seem to influence the results of ART (p>0.05). Conclusion: It is possible to achieve as high as 22% success rates of pregnancy even in the presence of high MAR values. Corticotherapy did not influence ART results. Smoking has a negative effect ART results.
Introduction: Retrospective analysis of the results of assisted reproductive techniques (ART) of infertile males with high mixed anti-globulin reactions (MAR). Materials and Methods: Data of 69 infertile male patients with high mixed anti-globulin reactions values (>15%) treated in Ege University IVF Centre between 1997 and 2005 were retrospectively evaluated. Various assisted reproductive techniques (ART): Intrauterine inseminations (IUI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) were applied to all patients. The influences of high MAR values on ART were analyzed. Patients were also categorized with regards to smoking and receiving corticotherapy before treatment. SPSS 13.0 for Windows XP were used for statistical analysis. Results: Mean patients age was 35.5±3.9 years old. Mean MAR value was 84±0.2%. A total of 87 ART were applied (65 IUI, 18 ICSI and 4 IVF). Out of 69 patients 21 (30.4%) of them received corticosteroids before any ART for 3 months. ART were successful in 15 infertile couples: 5 IUI (success: 6.1%); 9 ICSI (success: 50%); 1 IVF (success: 25%) and unsuccessful in 54 infertile couples. We had 15 successful ART and only 6 of them (42.86%) were instructed corticotherapy before ART and this constituted 28.5% of patients receiving corticotherapy. We had 15 successful and 54 unsuccessful ART cycles out of 69 couples. Male partner had an anamnesis about smoking at 53% and 80% of couples with successful and unsuccessful ART cycles respectively and the difference was statistically significant (p<0.05). Corticotherapy did not seem to influence the results of ART (p>0.05). Conclusion: It is possible to achieve as high as 22% success rates of pregnancy even in the presence of high MAR values. Corticotherapy did not influence ART results. Smoking has a negative effect ART results.
Açıklama
Anahtar Kelimeler
Üroloji ve Nefroloji
Kaynak
Türk Üroloji Dergisi/Turkish Journal of Urology
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
2
