A Functional Platform for the Detection of JWH-073 as a Model for Synthetic Cannabinoids

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dc.contributor.authorSengel, Tulay Yilmaz
dc.contributor.authorCelik, Emine Guler
dc.contributor.authorAydogan, Cansu
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorIlktac, Raif
dc.contributor.authorAydindogan, Eda
dc.contributor.authorCiftci, Mustafa
dc.contributor.authorAldemir, Ebru
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T10:06:15Z
dc.date.available2019-10-27T10:06:15Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractDuring the last decade, progress has been made in the on-site detection of abused drug use. Herein, we present an electrochemical biosensor for the detection of one of the synthetic cannabinoids (SCs), JWH-073, using poly (methyl methacrylate) (PMMA) hyperbranched copolymer (HBC) as a base coating and antibody molecules to bind the JWH-073 to the surface. Modification of the surface is proved with various techniques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectrometry. The limit of detection and linearity (in logarithmic scale) for JWH-073 were found to be 31.87 ng/mL and 25-500 ng/mL, respectively. The selectivity of the proposed biosensor was also tested in the presence of interfering molecules and the response was much higher for JWH-073 in all measurements. In the final part of the study, synthetic urine was tested with the device and the relative standard deviation value was calculated to be less than 5.0%. The confirmation of data from the resulting bio-platform was performed via LC-QTOF/MS. This work is the first of its kind, a novel, rapid, cost-effective sensing platform for the detection of the SC.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016 K121190]; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117Z152]; Istanbul Technical UniversityIstanbul Technical Universityen_US
dc.description.sponsorshipThis work was supported by Republic of Turkey, Ministry of Development (Project Grant No: 2016 K121190) and Scientific and Technological Research Council of Turkey (TUBITAK, Project Grant No: 117Z152). The research was also partially supported by Istanbul Technical University Research Fund.en_US
dc.identifier.doi10.1002/celc.201800015
dc.identifier.endpage1258en_US
dc.identifier.issn2196-0216
dc.identifier.issn2196-0216en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1253en_US
dc.identifier.urihttps://doi.org/10.1002/celc.201800015
dc.identifier.urihttps://hdl.handle.net/11454/30437
dc.identifier.volume5en_US
dc.identifier.wosWOS:000431624300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemelectrochemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsynthetic cannabinoidsen_US
dc.subjectsurface modificationen_US
dc.subjectJWH-073en_US
dc.subjectdrug abuseen_US
dc.subjecthyperbranched polymersen_US
dc.titleA Functional Platform for the Detection of JWH-073 as a Model for Synthetic Cannabinoidsen_US
dc.typeArticleen_US

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