Effects of pesticides used in agriculture on the development of precocious puberty

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dc.contributor.authorOzen S.
dc.contributor.authorDarcan S.
dc.contributor.authorBayindir P.
dc.contributor.authorKarasulu E.
dc.contributor.authorSimsek D.G.
dc.contributor.authorGurler T.
dc.date.accessioned2019-10-26T21:46:35Z
dc.date.available2019-10-26T21:46:35Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study aims to evaluate the effects of pesticides on premature breast development. Forty-five girls (group 1) with premature breast development living in the Menderes region, where greenhouse cultivation is the main income, 16 girls (group 2) living in Izmir city with early puberty, and 33 girls (group 3) who had no signs of puberty were included in the study. Endosulphan 1, endosulphan 2, endosulphan sulphate, methoxychlor, vinclozolin, 4,4-dichlorodiphenyldichlorethylene (DDE), 4,-dichloro-diphenyltrichloroethane (DDT), and 2,4-DDT were evaluated in the serum and adipose tissues of the groups by using a gas chromatography-mass spec-trometry method. With the exception of 4,4'-DDE, the pesticides studied were undetectable in the serum and adipose tissue samples. The levels of basal luteinizing hormone (LH), stimulated LH, follicle-stimulating hormone, and the long axis of the uterus and both ovaries were significantly different in the girls who had premature thelarche and detectable 4,4'-DDE levels compared to the girls who had premature thelarche and undetectable 4,4'-DDE levels in serum and adipose tissues. The presence and levels of pesticides in serum and adipose tissues were not related to precocious puberty (PP). The mechanisms that lead to PP may also result in obesity, and obesity may be the underlying cause for PP in this group. © Springer Science+Business Media B.V. 2011.en_US
dc.description.sponsorshipUniversity Research Committee, Emory University, URCen_US
dc.description.sponsorshipAcknowledgments This study was supported by the Ege University Research Committee. --en_US
dc.identifier.doi10.1007/s10661-011-2257-6en_US
dc.identifier.endpage4232en_US
dc.identifier.issn0167-6369
dc.identifier.issue7en_US
dc.identifier.pmid21805074en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4223en_US
dc.identifier.urihttps://doi.org/10.1007/s10661-011-2257-6
dc.identifier.urihttps://hdl.handle.net/11454/18566
dc.identifier.volume184en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEnvironmental Monitoring and Assessmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnvironmental endocrine disruptorsen_US
dc.subjectPesticidesen_US
dc.subjectPrecocious pubertyen_US
dc.titleEffects of pesticides used in agriculture on the development of precocious pubertyen_US
dc.typeArticleen_US

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