Evaluation of antibody responses in healthcare workers before & after meningococcal vaccine and determination of meningococcal carriage rates

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dc.contributor.authorElik, Dilsah Baskol
dc.contributor.authorYildirim, Cigdem
dc.contributor.authorSeyhan, Deniz Akyol
dc.contributor.authorErdem, Huseyin Aytac
dc.contributor.authorZeytinoglu, Aysin
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorAydemir, Sabire Sohret
dc.date.accessioned2024-08-31T07:49:46Z
dc.date.available2024-08-31T07:49:46Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe rates of nasopharyngeal meningococcal carriage in healthcare workers are unknown. Meningococcal vaccine is recommended for risk groups but healthcare workers are not included in risk groups for many countries. Herein, we aimed to investigate the nasopharyngeal meningococcal carriage rates, basal and after one dose of Men-ACWY-DT vaccine response on the 30th day by evaluating meningococcus IgG antibody levels and decolonization at month six after vaccination among the detected carriers. Nasopharyngeal swab samples were taken before vaccination to evaluate meningococcal carriage in healthcare workers. All participants received a single dose of Men-ACWY-DT vaccine. Serum samples were collected immediately before vaccination and again on day 30 post-vaccination. Antibodies in the stored sera were analyzed using the ELISA method. Participants who were determined to carry meningococci at the initial visit underwent another round of nasopharyngeal swab tests six months post-vaccination to check for decolonization. Between November 2020 and May 2021, we evaluated samples from 100 physicians [52 % females, 28.28 +/- 4.45 (min: 24, max: 49)]. The majority of the physicians worked in the emergency department (45 %), followed by the infectious diseases clinic (14 %). Fifty-eight physicians had a history of at least one contact with a meningococcus-infected patient, and 53 (91.4 %) had used prophylactic antibiotics at least once due to this exposure. None of the study group nasopharyngeal swab cultures were positive for Neisseria meningitidis. Before the Men-ACWY-DT vaccine, anti-meningococcus IgG positivity was detected in the serum samples of only 3 (3 %) participants. By day 30 after vaccination, 48 % of participants showed positive for antibodies. As we didn't detect nasopharyngeal carriage in any participants, we didn't evaluate decolonization among carriers six months post-vaccination. Notably, detection of antibodies was evident in about half of the participants on day 30 after receiving a single dose of the Men-ACWY-DT vaccine.en_US
dc.description.sponsorshipEge University Rectorate Scientific Research Projects Coordination Unit [21891]en_US
dc.description.sponsorshipBudgetary support for this study was provided by the Ege University Rectorate Scientific Research Projects Coordination Unit (Project No: 21891, dated November 3, 2020) .en_US
dc.identifier.doi10.1016/j.vaccine.2024.05.004
dc.identifier.endpage3967en_US
dc.identifier.issn0264-410X
dc.identifier.issn1873-2518
dc.identifier.issue19en_US
dc.identifier.pmid38719693en_US
dc.identifier.scopus2-s2.0-85192326168en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3961en_US
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2024.05.004
dc.identifier.urihttps://hdl.handle.net/11454/104993
dc.identifier.volume42en_US
dc.identifier.wosWOS:001287667100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofVaccineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNeisseria Meningitidisen_US
dc.subjectNasopharyngeal Carriageen_US
dc.subjectMeningococcal Carriageen_US
dc.subjectVaccinationen_US
dc.subjectHealthcare Workeren_US
dc.titleEvaluation of antibody responses in healthcare workers before & after meningococcal vaccine and determination of meningococcal carriage ratesen_US
dc.typeArticleen_US

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