Role of Autophagy in Breast Cancer Development and Progression: Opposite Sides of the Same Coin

Basit Öğe Kaydı
dc.contributor.authorRomero, Mirna Azalea
dc.contributor.authorEkmekcigil, Oznur Bayraktar
dc.contributor.authorBagca, Bakiye Goker
dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorSabitaliyevich, Uteuliyev Yerzhan
dc.contributor.authorZhenisovna, Tokmurziyeva Gulnara
dc.contributor.authorFarooqi, Ammad Ahmad
dc.date.accessioned2020-12-01T12:09:49Z
dc.date.available2020-12-01T12:09:49Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionAvci, Cigir Biray/0000-0001-8251-4520; Farooqi, Ammad/0000-0003-2899-5014en_US
dc.description.abstractThe term "autophagy", which means "self (auto) - eating (phagy)", describes a catabolic process that is evolutionarially conserved among all eukaryotes. Although autophagy is mainly accepted as a cell survival mechanism, it also modulates the process known as "type II cell death". AKT/mTOR pathway is an upstream activator of autophagy and it is tightly regulated by the ATG (autophagy-related genes) signaling cascade. in addition, wide ranging cell signaling pathways and non-coding RNAs played essential roles in the control of autophagy. Autophagy is closely related to pathological processes such as neurodegenerative diseases and cancer as well as physiological conditions. After the Nobel Prize in Physiology or Medicine 2016 was awarded to Yoshinori Ohsumi "for his discoveries of mechanisms for autophagy", there was an explosion in the field of autophagy and molecular biologists started to pay considerable attention to the mechanistic insights related to autophagy in different diseases. Since autophagy behaved dualistically, both as a cell death and a cell survival mechanism, it opened new horizons for a deeper -analysis of cell type and context dependent behavior of autophagy in different types of cancers. There are numerous studies showing that the induction of autophagy mechanism will promote survival of cancer cells. Since autophagy is mainly a mechanism to keep the cells alive, it may protect breast cancer cells against stress conditions such as starvation and hypoxia. For these reasons, autophagy was noted to be instrumental in metastasis and drug resistance. in this chapter we have emphasized on role of role of autophagy in breast cancer. Additionally we have partitioned this chapter into exciting role of microRNAs in modulation of autophagy in breast cancer. We have also comprehensively summarized how TRAIL-mediated signaling and autophagy operated in breast cancer cells.en_US
dc.identifier.doi10.1007/978-3-030-20301-6_5en_US
dc.identifier.endpage73en_US
dc.identifier.isbn978-3-030-20301-6; 978-3-030-20300-9
dc.identifier.issn0065-2598
dc.identifier.issn2214-8019
dc.identifier.pmid31456180en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1007/978-3-030-20301-6_5
dc.identifier.urihttps://hdl.handle.net/11454/63579
dc.identifier.volume1152en_US
dc.identifier.wosWOS:000514550100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofBreast Cancer Metastasis and Drug Resistance: Challenges and Progress, 2Nd Editionen_US
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutophagyen_US
dc.subjectBreast canceren_US
dc.subjectApoptosisen_US
dc.subjectSignalingen_US
dc.titleRole of Autophagy in Breast Cancer Development and Progression: Opposite Sides of the Same Coinen_US
dc.typeBook Chapteren_US

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