Antifungal susceptibility pattern of Candida auris strains: Analysis of clinical strains in a tertiary-care educational university hospital

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dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.contributor.authorKhairy, Amira
dc.contributor.authorHejres, Suha
dc.contributor.authorElbahr, Umran
dc.contributor.authorDayyab, Farouq
dc.contributor.authorDelos Reyes, Clark Steven
dc.contributor.authorPastrana, Jennie Ann
dc.contributor.authorVineeth, Chithra
dc.date.accessioned2024-08-31T07:48:18Z
dc.date.available2024-08-31T07:48:18Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractHerein, we aimed to investigate the antifungal susceptibility pattern of Candida auris clinical strains in our setting Bahrain Oncology Center-King Hamad University Hospital-Bahrain. C. auris strains isolated from different clinical specimens in the Microbiology Laboratory from October-2021 to November-2022 were evaluated. Species-level identification of fungi was performed by MALDI-TOF (Bruker, Germany). Minimum inhibitory concentration (MIC) was determined either by E-test strips or by MICRONAUT MIC system based on CDC guidelines for C. auris antifungal interpretation. Fluconazole, amphotericin-B, voriconazole, and caspofungin susceptibility data of the clinical strains were analyzed. A total of 40 clinical isolates were included: 25% were blood culture isolates, 65% were urinary, and 10% were soft tissue isolates. Only 29 strains could be tested for amphotericin-B and 32 for voriconazole. Overall resistance pattern was as follows: 100% resistance to fluconazole, 2.5% resistance to caspofungin, and 0% resistance to amphotericin b. Median voriconazole MIC was 0.015 ug/ml (min 0.08, max= 0.064 ug/ml). We had no fluconazole-sensitive strain and only one caspofungin-resistant strain. A single isolate (2.5%), which was associated with candidemia, demonstrated resistance to two antifungal agents: fluconazole and caspofungin. No triple or quadruple drug resistant strain existed.en_US
dc.identifier.endpage156en_US
dc.identifier.issn1121-7138
dc.identifier.issue2en_US
dc.identifier.pmid39023524en_US
dc.identifier.scopus2-s2.0-85199127450en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://hdl.handle.net/11454/104719
dc.identifier.volume47en_US
dc.identifier.wosWOS:001272981900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Int Srlen_US
dc.relation.ispartofNew Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectEpidemiologyen_US
dc.subjectCandidemiaen_US
dc.subjectAntifungalen_US
dc.subjectCandiduriaen_US
dc.titleAntifungal susceptibility pattern of Candida auris strains: Analysis of clinical strains in a tertiary-care educational university hospitalen_US
dc.typeArticleen_US

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