The carcinogenic effect of diethylnitrosamine in rats and the preventive role of chloramphenicol in such cases
Küçük Resim Yok
Tarih
1973
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A total of 104 rats was divided into groups of 60, 30 and 14. The first group received 1.2 mg/kg diethylnitrosamine (DENA) orally for 18 mth; the second group, 1.5 mg/Kg DENA for 14 mth; and the third group, 1.5 mg/Kg DENA for 11 mth. Each group was divided into test and control subgroups. Chloramphenicol, added to make 2% of the ground food, was given to the rats in the control subgroups in addition to DENA. Routine autopsies were carried out on animals that died normally, and tumoral and nontumoral changes were examined. Most of the tumoral changes were in the liver following the administration of DENA. In a minor degree some changes were also encountered in bile ducts, lymphoid tissue, kidneys and the mucosal lining of the stomach. The preventive role of chloramphenicol against the carcinogenic effect was studied also.
Açıklama
Anahtar Kelimeler
Kaynak
Aegean Medical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
272
