Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy

Basit Öğe Kaydı
dc.authoridRoyo-Cebrecos, Cristina/0000-0003-2554-4656
dc.authoridSipahi, Oguz Resat/0000-0002-1243-2746
dc.authoridMaestro de la Calle, Guillermo/0000-0002-7317-5157
dc.authoridAYAZ, CAGLAYAN MERVE/0000-0003-2574-8683
dc.authoridda Silva Machado, Amanda Aparecida/0000-0002-5779-1611
dc.authoridRuiz- Camps, Isabel/0000-0003-3743-2379
dc.authoridGarcia-Vidal, Carolina/0000-0002-8915-0683
dc.contributor.authorRoyo-Cebrecos, Cristina
dc.contributor.authorLaporte-Amargos, Julia
dc.contributor.authorPena, Marta
dc.contributor.authorRuiz-Camps, Isabel
dc.contributor.authorGarcia-Vidal, Carolina
dc.contributor.authorAbdala, Edson
dc.contributor.authorOltolini, Chiara
dc.date.accessioned2024-08-31T07:50:12Z
dc.date.available2024-08-31T07:50:12Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThis large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented with septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-risk Multinational Association for Supportive Care in Cancer (MASCC) index score (92.6% vs. 57.4%; p < 0.001), pneumonia (38% vs. 19.2% p < 0.001), and infection due to multidrug-resistant P. aeruginosa (MDRPA) (33.8% vs. 21.1%, p < 0.001) were statistically significantly higher in patients with septic shock compared to those without. Patients with septic shock were more likely to receive inadequate empirical antibiotic therapy (IEAT) (21.7% vs. 16.2%, p = 0.020) and to present poorer outcomes, including a need for ICU admission (74% vs. 10.5%; p < 0.001), mechanical ventilation (49.1% vs. 5.6%; p < 0.001), and higher 7-day and 30-day case fatality rates (58.2% vs. 12%, p < 0.001, and 74% vs. 23.1%, p < 0.001, respectively). Risk factors for 30-day case fatality rate in patients with septic shock were orotracheal intubation, IEAT, infection due to MDRPA, and persistent PABSI. Therapy with granulocyte colony-stimulating factor and BSI from the urinary tract were associated with improved survival. Carbapenems were the most frequent IEAT in patients with septic shock, and the use of empirical combination therapy showed a tendency towards improved survival. Our findings emphasize the need for tailored management strategies in this high-risk population.en_US
dc.description.sponsorshipInstituto de Salud Carlos III; Subdireccion Generalde Redes y Centros de Investigacion Cooperativa; Ministerio de Economia, Industria y Competitividad; Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain [CB21/13/00009, CB21/13/00079, CB21/13/00054, CB21/13/00086]en_US
dc.description.sponsorshipThis study was supported by the Instituto de Salud Carlos III, Subdireccion Generalde Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC)(CB21/13/00009; CB21/13/00079; CB21/13/00054; CB21/13/00086), Madrid, Spain.en_US
dc.identifier.doi10.3390/microorganisms12040705
dc.identifier.issn2076-2607
dc.identifier.issue4en_US
dc.identifier.pmid38674650en_US
dc.identifier.scopus2-s2.0-85191686629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/microorganisms12040705
dc.identifier.urihttps://hdl.handle.net/11454/105140
dc.identifier.volume12en_US
dc.identifier.wosWOS:001211147400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMicroorganismsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectPseudomonas Aeruginosaen_US
dc.subjectBacteremiaen_US
dc.subjectSeptic Shocken_US
dc.subjectBloodstream Infectionen_US
dc.subjectNeutropeniaen_US
dc.subjectCanceren_US
dc.titlePseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu