Autoimmune hepatitis and long-term disease course in children in Turkey, a single-center experience

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dc.contributor.authorKarakoyun, Miray
dc.contributor.authorEcevit, Cigdem O.
dc.contributor.authorKilicoglu, Erhan
dc.contributor.authorAydogdu, Sema
dc.contributor.authorYagci, Rasit V.
dc.contributor.authorOzgenc, Funda
dc.date.accessioned2019-10-27T23:09:08Z
dc.date.available2019-10-27T23:09:08Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction The aim of this study is to determine clinic and laboratory features, treatment protocols, treatment responses, and long term follow-up of children with autoimmune hepatitis (AIH) in a region of Turkey followed at Ege University. Materials and methods The records of 47 children with AIH between 1998 and 2012 were retrospectively analyzed for clinical profiles, treatment response, relapse rate, and long-term side effects. Results The median age of the children was 10 +/- 4.1 years (55.3% females). A total of 29 patients presented with chronic hepatitis (61.7%). According to the autoantibody profiles, 40 (85.1%) and seven (14.9%) cases were classified as type 1 and type 2, respectively. Presentation with acute hepatitis and chronic hepatitis was significantly higher in type 1 disease. Laboratory findings at presentation was found similar among races as well as AIH types (P>0.05). The prednisolone was used for remission induction in 37 patients; 86.4% (n: 32) achieved a complete response, 2.7% (n: 1) achieved a partial response, and four patients (10.8%) showed no response. Maintenance was attained by low-dose steroid plus thiopurine and relapse in steroid responders (n: 32) was 9.4% (n: 3) at 8, 12, and 48 months. A total of 36% (n: 24) had neither acute nor chronic treatment side effects. Bone marrow suppression was observed in five patients and hyperglycemia was observed in one patient (10.6 and 2.1%), respectively. Conclusion AIH type 1 prevails in children in a region of Turkey during the second decade of life. Low-dose corticosteroids combined with azathioprine are found. Eur J Gastroenterol Hepatol 28:927-930 Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.identifier.doi10.1097/MEG.0000000000000648en_US
dc.identifier.endpage930en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue8en_US
dc.identifier.pmid27254777en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage927en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000000648
dc.identifier.urihttps://hdl.handle.net/11454/52531
dc.identifier.volume28en_US
dc.identifier.wosWOS:000379310600012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautoimmune hepatitisen_US
dc.subjectprevalenceen_US
dc.subjectsteroiden_US
dc.titleAutoimmune hepatitis and long-term disease course in children in Turkey, a single-center experienceen_US
dc.typeArticleen_US

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