MMP-2 and MMP-9 Alteration in Response to Collaring in Rabbits: The Effects of Endothelin Receptor Antagonism

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dc.contributor.authorReel, Buket
dc.contributor.authorOktay, Gulgun
dc.contributor.authorOzkal, Sermin
dc.contributor.authorIslekel, Huray
dc.contributor.authorOzer, Erdener
dc.contributor.authorOzsarlak-Sozer, Gonen
dc.contributor.authorCavdar, Zahide
dc.contributor.authorAkhisaroglu, Serpil Tanriverdi
dc.contributor.authorKerry, Zeliha
dc.date.accessioned2019-10-27T21:19:16Z
dc.date.available2019-10-27T21:19:16Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractMatrix metalloproteinases (MMPs), and, in particular, gelatinases (MMP-2 and MMP-9), have been implicated in vascular cell proliferation and/or migration, contributing to intimal thickening, an essential stage in the development of atherosclerosis and restenosis following balloon angioplasty. Endothelin, a strong chemoatractant and mitogen, has been shown to promote smooth muscle cell proliferation and migration by activating MMPs via endothelin-A (ETA) receptors. The positioning of a soft silicon collar around the left carotid artery in rabbits results in intimal thickening. In this study, we investigate the possible role of gelatinases and the effect of a nonselective ETA/ETB receptor antagonist, TAK-044 (5 mg/kg body weight/day, subcutaneously [sc]), on these enzymes. Our results demonstrated that both MMP-2 and MMP-9 activities increased in response to collaring in placebo group, while treatment with TAK-044 significantly suppressed both gelatinase activities and proMMP-2 levels, and inhibited intimal thickening in collared arteries. These results suggest that either enhanced MMP expression or endothelin receptor antagonism may be involved in the formation of intimal thickening in this model.en_US
dc.description.sponsorshipNovartis Pharmaceutical Company Pharmacological Research Grant; Ege University Science and Technology Centre (EBILTEM) Research Project AdministrationEge University [2004 BIL 002, ZK]en_US
dc.description.sponsorshipAuthors would like to thank TAKEDA Chemical Industries, Ltd., Japan, for kindly providing us with a sample of TAK-044. This work was substantially supported by a grant of Novartis Pharmaceutical Company Pharmacological Research Grant for 2003, Istanbul, Turkey (ZK) and also by Ege University Science and Technology Centre (EBILTEM) Research Project Administration (2004 BIL 002, ZK).en_US
dc.identifier.doi10.1177/1074248409343690en_US
dc.identifier.endpage301en_US
dc.identifier.issn1074-2484
dc.identifier.issn1940-4034
dc.identifier.issue4en_US
dc.identifier.pmid19734325en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage292en_US
dc.identifier.urihttps://doi.org/10.1177/1074248409343690
dc.identifier.urihttps://hdl.handle.net/11454/44122
dc.identifier.volume14en_US
dc.identifier.wosWOS:000271727400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Cardiovascular Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectmatrix metalloproteinaseen_US
dc.subjectendothelin antagonismen_US
dc.subjectrabbiten_US
dc.subjectcollaren_US
dc.titleMMP-2 and MMP-9 Alteration in Response to Collaring in Rabbits: The Effects of Endothelin Receptor Antagonismen_US
dc.typeArticleen_US

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