Glycosaminoglycan-induced proinflammatory cytokine levels as disease marker in mucopolysaccharidosis

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Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Academic Press

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Recently, it has been shown disturbances in oxidant/antioxidant system and increases in some inflammatory markers in animal studies and in some Mucopolysaccharidoses (MPSs) patients. In this study, we aimed to determine the oxidative stress/antioxidant parameters and pro-inflammatory cytokine levels in the serum of MPS patients, in order to evaluate the possible role of inflammation in these patient groups regarding to accumulated metabolites. MPS I (n = 3), MPS II (n = 8), MPS III (n = 4), MPS IVA (n = 3), MPS VI (n = 3), and VII (n = 1) patients and 20 age-matched healthy subjects were included into the study. There was no statistically significant change in activities of SOD, Catalase, GSH-Px and lipid peroxidation levels in erythrocytes between the MPS patients and healthy controls. While IL-1alpha (p = 0.054), IL-6 (p = 0.008) levels, and chitotriosidase activity (p = 0.003) elevated in MPS3 patients, IL1? (p = 0.006), IL-1? (p = 0.006), IL-6 (p = 0.006), IFN? (p = 0.006), and NF?B (p = 0.006) levels increased in MPS-6 patients. Elevated levels of IL-6, IL1? and chitotriosidase activity demonstrated macrophage activation in MPSIII untreated with enzyme replacement. Our study showed for the first time that high levels of IL1?, IL-6, IL1? and NF?B were present in MPSVI patients, demonstrating the induction of inflammation by dermatan sulphate. The low level of paraoxonase in MPSVI patients may be a good marker for cardiac involvement. Overall, this study provides important insights into the relationship between lysosomal storage of glycosaminoglycan and inflammation in MPS patients. It highlights possible pathways for the increased release of inflammatory molecules and suggests new targets for the development of treatments. © 2023 Elsevier Ltd

Açıklama

Anahtar Kelimeler

Inflammation, Mucopolysaccharidosis, Paraoxonase, aryldialkylphosphatase, catalase, chitotriosidase, cytokine, dermatan sulfate, gamma interferon, glutathione peroxidase, glycosaminoglycan, immunoglobulin enhancer binding protein, interleukin 1alpha, interleukin 1beta, interleukin 6, superoxide dismutase, adolescent, adult, antioxidant activity, Article, child, clinical article, controlled study, enzyme deficiency, enzyme replacement, erythrocyte, female, heart disease, human, Hunter syndrome, Hurler syndrome, inflammation, lipid peroxidation, lysosome storage disease, macrophage activation, male, Maroteaux Lamy syndrome, metabolite, Morquio syndrome, mucopolysaccharidosis, mucopolysaccharidosis type 7, oxidative stress, Sanfilippo syndrome

Kaynak

Cytokine

WoS Q Değeri

Scopus Q Değeri

Q2

Cilt

173

Sayı

Künye