The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy

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dc.authoridGunduz, Cumhur/0000-0002-6593-3237
dc.authoridGökhan, Aylin/0000-0002-6254-157X
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.authoridAcikgoz, Eda/0000-0002-6772-3081
dc.authoridYigitturk, Gurkan/0000-0002-5315-253X
dc.authoridBUHUR, Aylin/0000-0002-3759-6616
dc.authorscopusid56376463500
dc.authorscopusid55469991100
dc.authorscopusid8633854100
dc.authorscopusid56364984200
dc.authorscopusid57207940063
dc.authorscopusid57219907255
dc.authorscopusid57208215503
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.authorwosidGunduz, Cumhur/GOP-0629-2022
dc.authorwosidGUREL, ÇEVİK/AAA-1277-2021
dc.authorwosidGökhan, Aylin/AAE-2494-2019
dc.authorwosidAcikgoz, eda/W-2171-2017
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.contributor.authorKarabay Yavasoglu, Nefise Ulku
dc.contributor.authorAcikgoz, Eda
dc.contributor.authorBuhur, Aylin
dc.contributor.authorGokhan, Aylin
dc.contributor.authorGurel, Cevik
dc.date.accessioned2023-01-12T19:59:06Z
dc.date.available2023-01-12T19:59:06Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractDiabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. The aim of the current study was to determine the effect of intramuscular adipose-derived mesenchymal stem cell (AMSC) transplantation on sciatic nerves in DN using EMG and histological analyses. A total of 27 mice were randomly divided into three groups: control group, DN group and AMSC group. In EMG, CMAP amplitude in the sciatic nerves was lower, but distal latency was higher in the DN group compared with the control group. CMAP amplitude in the sciatic nerves was higher in the AMSC group compared with the DN group. Distal latency in the sciatic nerve was lower in the AMSC group compared with the DN group. Histologic examination of the tissues in the animals treated with AMSC showed a remarkable improvement in microscopic morphology. Fluorescence microscopy analyses demonstrated that intramuscularly transplanted AMSC was selectively localized in the sciatic nerves. Transplantation of AMSC increased protein expression of S100, cdk2, NGF and DHH, all of which, interfered with DN onset in sciatic nerves. The findings of the present study suggest that AMSC transplantation improved DN through a signal-regulatory effect on Schwann cells, neurotrophic actions and restoration of myelination.en_US
dc.description.sponsorshipEge University Faculty of Medicine Histology and Embryology Laboratoriesen_US
dc.description.sponsorshipEge University Faculty of Medicine Histology and Embryology Laboratories.en_US
dc.identifier.doi10.1080/01616412.2021.1967679
dc.identifier.endpage164en_US
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue2en_US
dc.identifier.pmid34410214en_US
dc.identifier.scopus2-s2.0-85113226755en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://doi.org/10.1080/01616412.2021.1967679
dc.identifier.urihttps://hdl.handle.net/11454/77099
dc.identifier.volume44en_US
dc.identifier.wosWOS:000686409800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectadipose-derived mesenchymal stem cellen_US
dc.subjectschwann cellen_US
dc.subjectemgen_US
dc.subjects100en_US
dc.subjectcdk2en_US
dc.subjectngfen_US
dc.subjectdhhen_US
dc.subjectNerve Growth-Factoren_US
dc.subjectExpressionen_US
dc.subjectRecoveryen_US
dc.subjectHedgehogen_US
dc.titleThe neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathyen_US
dc.typeArticleen_US

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