Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function

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dc.authoridBOLAT, HILMI/0000-0001-6574-8149
dc.authorscopusid57184185700
dc.authorscopusid57193656880
dc.authorscopusid57212220169
dc.authorscopusid16444898100
dc.authorscopusid57214880787
dc.authorscopusid35461622300
dc.authorscopusid7003907434
dc.authorwosidBolat, Hilmi/GSE-3106-2022
dc.contributor.authorBolat, Hilmi
dc.contributor.authorUnsel-Bolat, Gul
dc.contributor.authorOzgul, Semiha
dc.contributor.authorPariltay, Erhan
dc.contributor.authorTahillioglu, Akin
dc.contributor.authorRohde, Luis Augusto
dc.contributor.authorAkin, Haluk
dc.date.accessioned2023-01-12T19:59:24Z
dc.date.available2023-01-12T19:59:24Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder and Sluggish Cognitive Tempo (SCT) might be a second inattention disorder that might be even affected by different attention pathways. SCT is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. In the present study, we evaluated 5 common variants (rs6265, rs3746544, rs1051312, rs133946 and rs133945) located in 3 candidate genes (BDNF, SNAP25 and SYN III) that are known to take part in synaptic plasticity and neurotransmitter transmission. Methods We tested the effects of these variants on neuropsychological findings assessed by a computer-based neuropsychological test battery in children with inattention symptoms (SCT and/or ADHD). Results BDNF (rs6265), SNAP25 (rs3746544 and rs1051312) and SYN III (rs133946 and rs133945) polymorphisms were associated with variable cognitive measures. BDNF gene (rs6265) polymorphism Met allele carriers and SNAP25 gene (rs3746544) T allele carriers had an association with the attention domain. SNAP25 gene (rs1051312) C allele carriers were only associated with reaction time scores. Cognitive flexibility, which is one of the key components of executive function evaluation and shifting attention test scores were associated with BDNF (rs6265) Met allele and SYN III (rs133946) gene G allele. SYN III (rs133945) gene C allele carriers had an association with verbal memory correct hit scores. Conclusions As a conclusion, BDNF, SNAP25 and SYN III genes were associated with specific neurocognitive outcomes in children with inattention symptoms. It is important to note that exploring genotyping effects on neurocognitive functions instead of a heterogeneous psychiatric diagnosis can improve our understanding of psychopathologies.en_US
dc.description.sponsorshipEge University [TTU-2018-20009]en_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Projects Coordinator [TTU-2018-20009].en_US
dc.identifier.doi10.1080/08039488.2022.2027518
dc.identifier.endpage615en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue8en_US
dc.identifier.pmid35077325en_US
dc.identifier.scopus2-s2.0-85123872215en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2022.2027518
dc.identifier.urihttps://hdl.handle.net/11454/77164
dc.identifier.volume76en_US
dc.identifier.wosWOS:000746774600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitive measuresen_US
dc.subjectinattentionen_US
dc.subjectconcentration deficiten_US
dc.subjectexecutive functionen_US
dc.subjectgeneticsen_US
dc.subjectDeficit-Hyperactivity Disorderen_US
dc.subjectSluggish Cognitive Tempoen_US
dc.subjectFactor Val66met Polymorphismen_US
dc.subjectSynapsin-Iiien_US
dc.subjectDeficit/Hyperactivity Disorderen_US
dc.subjectCandidate Geneen_US
dc.subjectSnap25 Geneen_US
dc.subjectChildrenen_US
dc.subjectDopamineen_US
dc.subjectValidityen_US
dc.titleInvestigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive functionen_US
dc.typeArticleen_US

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