Brain areas associated with resilience to depression in high-risk young women

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dc.contributor.authorBurhanoglu, Birce Begum
dc.contributor.authorDincer, Gulsah
dc.contributor.authorYilmaz, Alpaslan
dc.contributor.authorOzalay, Ozgun
dc.contributor.authorUslu, Ozgul
dc.contributor.authorUnaran, Esmin
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2021-05-03T20:28:07Z
dc.date.available2021-05-03T20:28:07Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractPrevious structural brain-imaging studies in first-degree relatives of depressed patients showed alterations that are generally accepted as vulnerability markers for depression. However, only half of the relatives had depression at follow-up, while the other half did not. The aim of this study was to identify the brain areas associated with resilience to depression in high-risk subjects with familial depression. We recruited 59 young women with a history of depressed mothers. Twenty-nine of them (high-risk group [HRG]) had no depression history, while 30 (depressive group) had at least 1 depressive episode in adolescence. The brain structures of the groups were compared through voxel-based morphometry and analysis of cortical thickness. Individual amygdala nuclei and hippocampal subfield volumes were measured. The analysis showed larger amygdala volume, thicker subcallosal cortex and bilateral insula in the women in the HRG compared with those in the depressive group. in addition, we detected more gray matter in the left temporal pole in the HRG. The larger gray matter volume and increased cortical thickness in the key hub regions of the salience network (amygdala and insula) and structurally connected regions in the limbic network (subcallosal area and temporal pole) might prevent women in the HRG from converting to depression.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S134]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (Project Number 109S134).en_US
dc.identifier.doi10.1007/s00429-021-02215-wen_US
dc.identifier.endpage888en_US
dc.identifier.issn1863-2653
dc.identifier.issn1863-2661
dc.identifier.issue3en_US
dc.identifier.pmid33458784en_US
dc.identifier.scopus2-s2.0-85099392250en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage875en_US
dc.identifier.urihttps://doi.org/10.1007/s00429-021-02215-w
dc.identifier.urihttps://hdl.handle.net/11454/69749
dc.identifier.volume226en_US
dc.identifier.wosWOS:000608391100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofBrain Structure & Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectHigh risken_US
dc.subjectVoxel-based morphometryen_US
dc.subjectCortical thicknessen_US
dc.subjectAmygdala nucleien_US
dc.subjectHippocampal subfieldsen_US
dc.titleBrain areas associated with resilience to depression in high-risk young womenen_US
dc.typeArticleen_US

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