Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: A comparative study

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dc.contributor.authorAkkol, Esra Kupeli
dc.contributor.authorSuntar, Ipek
dc.contributor.authorErdogan, Tugce Fafal
dc.contributor.authorKeles, Hikmet
dc.contributor.authorGonenc, Tuba Mert
dc.contributor.authorKivcak, Bijen
dc.date.accessioned2019-10-27T21:33:41Z
dc.date.available2019-10-27T21:33:41Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractEthnopharmacological relevance: In Turkish folk medicine Ranunculus species are used for wound healing and for the treatment of rheumatism. The present study was conducted to evaluate in vivo wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus. Material and methods: In vivo wound healing activity of the extracts prepared from Ranunculus pedatus and Ranunculus constantinapolitanus was evaluated by linear incision and circular excision wound models. Hydroxyproline content of the treated tissues was also assessed. We also studied the anti-inflammatory activity using Whittle method with some modifications. Results: Methanolic extract of Ranunculus pedatus showed significant wound healing effect both in incision (31.4%) and excision (55.74%) wound models. Methanolic extract of both Ranunculus pedatus and Ranunculus constantinapolitanus demonstrated anti-inflammatory activity with the inhibition value of 26.2% and 23.3% respectively, at the dose of 100 mg/kg. Hydroxyproline content of the tissues treated with the methanolic and aqueous extracts of Ranunculus pedatus and methanolic extract of Ranunculus constantinapolitanus were found to be significantly higher than that of the other extracts. Conclusion: The experimental data revealed that Ranunculus pedatus showed significant wound healing and anti-inflammatory effect. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jep.2011.11.037en_US
dc.identifier.endpage484en_US
dc.identifier.issn0378-8741
dc.identifier.issue2en_US
dc.identifier.pmid22143152en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage478en_US
dc.identifier.urihttps://doi.org/10.1016/j.jep.2011.11.037
dc.identifier.urihttps://hdl.handle.net/11454/45313
dc.identifier.volume139en_US
dc.identifier.wosWOS:000302505900022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal of Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectExcisionen_US
dc.subjectHydroxyprolineen_US
dc.subjectIncisionen_US
dc.subjectRanunculaceaeen_US
dc.subjectTensiometeren_US
dc.subjectWound healingen_US
dc.titleWound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: A comparative studyen_US
dc.typeArticleen_US

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