The reasons of poor lipid target attainment for secondary prevention in real life practice: Results from EPHESUS

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dc.contributor.authorMert, Gurbet Ozge
dc.contributor.authorBasaran, Ozcan
dc.contributor.authorMert, Kadir Ugur
dc.contributor.authorDogan, Volkan
dc.contributor.authorOzlek, Buelent
dc.contributor.authorCelik, Oguzhan
dc.contributor.authorOzlek, Eda
dc.contributor.authorCil, Cem
dc.contributor.authorOzdemir, Ibrahim Halil
dc.contributor.authorRencuzogullari, Ibrahim
dc.contributor.authorKaradeniz, Fatma Ozpamuk
dc.contributor.authorBekar, Lutfu
dc.contributor.authorAktas, Muejdat
dc.contributor.authorResulzade, Mubariz Murat
dc.contributor.authorKalcik, Macit
dc.contributor.authorAksan, Gokhan
dc.contributor.authorCinier, Goksel
dc.contributor.authorAkay, Kadriye
dc.contributor.authorPekel, Nihat
dc.contributor.authorSenol, Utku
dc.contributor.authorBiteker, Murat
dc.contributor.authorKayikcioglu, Meral
dc.date.accessioned2019-10-27T09:41:33Z
dc.date.available2019-10-27T09:41:33Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective There are lack of studies considering the suboptimal management of dyslipidemia especially in cardiology outpatient clinics. This study was conducted to assess the patient adherence to cholesterol treatment recommendations and attainment of low-density-lipoprotein cholesterol (LDL-C) goals. Methods EPHESUS (NCT02608645) is a national, observational and multicenter registry which has been designed as a cross-sectional study to allow inclusion of all consecutive patients with hypercholesterolemia in cardiology outpatient clinics. The present subgroup analyses of the EPHESUS trial included patients with known peripheral artery disease or atherosclerotic cerebrovascular disease, and coronary heart disease namely secondary prevention. Results The present analysis of the EPHESUS study included 1482 patients (62.79 +/- 10.4 years, 38.2% female) with secondary prevention from 40 sites in Turkey. Regarding recommended lipid targets for LDL-C, only 267 patients (18%) were below the target of 70 mg/dL. Females were significantly more off-target when compared with male patients (396, 85.5% vs 67, 14.5%; P = 0.017). Moreover, the achievement of LDL-C goal was significantly decreased with illiteracy (233, 19.2% vs 35, 13.1%; P = 0.02). Patients who think that the cholesterol treatment should be terminated when the cholesterol level of a patient has normalised were higher in the off-target group (34.0% vs 24.7%, P < 0.001). Besides, physician perceptions about LDL-C goal for secondary prevention were significantly related with LDL-C target attainment. Conclusions EPHESUS is an important study with large population in terms of representing real-life practice of the adherence to dyslipidemia guidelines in secondary prevention patients in Turkey. Perceptions, knowledge, and compliance with the guidelines for secondary prevention have increased, but it is far below from the desired levels even in cardiology outpatient clinics. There is a need for patients' and physicians' education regarding the treatment of hyperlipidemia.en_US
dc.identifier.doi10.1111/ijcp.13358en_US
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue9en_US
dc.identifier.pmid31038781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.13358
dc.identifier.urihttps://hdl.handle.net/11454/28646
dc.identifier.volume73en_US
dc.identifier.wosWOS:000483810100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe reasons of poor lipid target attainment for secondary prevention in real life practice: Results from EPHESUSen_US
dc.typeArticleen_US

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