Causative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study

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dc.contributor.authorHatipoglu, Mustafa
dc.contributor.authorMutluoglu, Mesut
dc.contributor.authorTurhan, Vedat
dc.contributor.authorUzun, Gunalp
dc.contributor.authorLipsky, Benjamin A.
dc.contributor.authorSevim, Erol
dc.contributor.authorDemiraslan, Hayati
dc.contributor.authorEryilmaz, Esma
dc.contributor.authorOzuguz, Cem
dc.contributor.authorMemis, Ali
dc.contributor.authorAy, Hakan
dc.contributor.authorArda, Bilgin
dc.contributor.authorUysal, Serhat
dc.contributor.authorMotor, Vicdan Koksaldi
dc.contributor.authorKader, Cigdem
dc.contributor.authorErturk, Ayse
dc.contributor.authorCoskun, Omer
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorGuler, Selma
dc.contributor.authorAltay, Fatma Aybala
dc.contributor.authorOgutlu, Aziz
dc.contributor.authorBolukcu, Sibel
dc.contributor.authorYildiz, Senol
dc.contributor.authorKandemir, Ozlem
dc.contributor.authorAslaner, Halide
dc.contributor.authorPolat, Arife
dc.contributor.authorKarahocagil, Mustafa K.
dc.contributor.authorYasar, Kadriye Kart
dc.contributor.authorSehmen, Emine
dc.contributor.authorKilic, Sirri
dc.contributor.authorSunbul, Mustafa
dc.contributor.authorGencer, Serap
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorYanik, Tugba
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorBatirel, Ayse
dc.contributor.authorSozen, Hamdi
dc.contributor.authorKilic, Inci
dc.contributor.authorCelik, Ilhami
dc.contributor.authorAy, Bengisu
dc.contributor.authorTosun, Selma
dc.contributor.authorKadanali, Ayten
dc.contributor.authorComoglu, Senol
dc.contributor.authorDenk, Affan
dc.contributor.authorHosoglu, Salih
dc.contributor.authorAydin, Ozlem
dc.contributor.authorElaldi, Nazif
dc.contributor.authorAkalin, Serife
dc.contributor.authorKandemir, Bahar
dc.contributor.authorAkbulut, Ayhan
dc.contributor.authorDemirdal, Tuna
dc.contributor.authorBalik, Recep
dc.contributor.authorAzak, Emel
dc.contributor.authorSengoz, Gonul
dc.date.accessioned2019-10-27T23:09:23Z
dc.date.available2019-10-27T23:09:23Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. Methods: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). Results: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. Conclusions: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2016.02.013en_US
dc.identifier.endpage916en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue5en_US
dc.identifier.pmid26965794en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2016.02.013
dc.identifier.urihttps://hdl.handle.net/11454/52629
dc.identifier.volume30en_US
dc.identifier.wosWOS:000378759700027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiotic therapyen_US
dc.subjectDiabetic footen_US
dc.subjectGuidelineen_US
dc.subjectInfectionen_US
dc.subjectTurkeyen_US
dc.titleCausative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center studyen_US
dc.typeArticleen_US

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