Altered IGF-I receptor expression in chorioamniotic cells in premature rupture of fetal membranes
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To investigate the presence and distribution of type I insulinlike growth factor receptor (IGF-IR) in the cells of the chorioamniotic membrane and to search for any alterations occurring in IGF-IR expression in premature rupture of membranes (PROM) patients. STUDY DESIGN: Fetal membranes collected at delivery from 42 pregnancies between 36 and 40 gestational weeks were included in the study. Seventeen of 42 cases had premature rupture of membranes, and 25 cases had intact membranes prior to delivery. Paraffin sections of the fetal membranes were stained with IGF-IR antibody by the streptavidin-biotin-immunoperoxidase method. The staining was scored and compared statistically between PROM and control cases. RESULTS: The fetal membranes of PROM cases had significantly reduced IGF-IR expression in chorionic trophoblastic cells when compared with the control group (P=.006, ? 2). CONCLUSION: Our immunohistochemical findings revealed that changes in IGF-IR levels in chorionic amniotic cells may play a pathogenetic role in PROM cases, but the mechanism is speculative and needs further investigation.
Açıklama
Anahtar Kelimeler
Fetal membranes, Fetal membranes, premature rupture, IGF-I receptor
Kaynak
Journal of Reproductive Medicine for the Obstetrician and Gynecologist
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
49
Sayı
6
