Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease

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dc.contributor.authorOzbaran, M
dc.contributor.authorOmay, SB
dc.contributor.authorNalbantgil, S
dc.contributor.authorKultursay, H
dc.contributor.authorKumanlioglu, K
dc.contributor.authorNart, D
dc.contributor.authorPektok, E
dc.date.accessioned2019-10-27T19:04:52Z
dc.date.available2019-10-27T19:04:52Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Ischemic heart disease accounts for 50% of all cardiovascular deaths and is the leading cause of congestive heart failure. Medical therapy, cardiac assist devices and surgical procedures including heart transplantation have limited efficiency and availability. Stem cell transplantation represents a new therapeutic opportunity for such patients. Method: Six patients with the diagnosis of ischemic cardiomyopathy were included in this study. All of the patients had clinical, radiological and echocardiographic signs of heart failure, and reduced left ventricular ejection fraction (LVEF less than or equal to25%). They underwent coronary angiography and stress tests with dobutamine echocardiography, thallium scintigraphy and positron emission tomography to assess myocardial ischemia and viability. Peripheral stem cells were mobilized and collected by apheresis. They were transplanted into areas of injury with open-heart surgery. To increase blood flow to the engrafted areas, coronary artery by-pass surgery was also performed. Results: The patients were followed at least for 4 months. Echocardiography, thallium scintigraphy and positron emission tomography were repeated after at least 6 weeks following surgery. There was a significant increase in life quality and NYHA class. Some benefit was documented on echocardiography, thallium scintigraphy, and positron emission tomography. Conclusion: This approach opens a new window in the treatment of 'no hope' patients with congestive heart failure. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejcts.2003.11.038en_US
dc.identifier.endpage350en_US
dc.identifier.issn1010-7940
dc.identifier.issue3en_US
dc.identifier.pmid15019658en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage342en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejcts.2003.11.038
dc.identifier.urihttps://hdl.handle.net/11454/38241
dc.identifier.volume25en_US
dc.identifier.wosWOS:000220286800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Cardio-Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectstem cellen_US
dc.subjectcongestive heart failureen_US
dc.subjecttransdifferentiationen_US
dc.subjectcell transplantationen_US
dc.titleAutologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart diseaseen_US
dc.typeArticleen_US

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