Expression of Cyclin D1 and Its Relationship to Hormone Receptors and Survival in Breast Cancer

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dc.contributor.authorAlanyali, Senem
dc.contributor.authorYeniay, Levent
dc.contributor.authorDemir, Derya
dc.contributor.authorAydin, Barbaros
dc.contributor.authorZekioglu, Osman
dc.contributor.authorOzdemir, Necmettin
dc.contributor.authorKitapcioglu, Gul
dc.contributor.authorHaydaroglu, Ayfer
dc.date.accessioned2019-10-27T11:18:55Z
dc.date.available2019-10-27T11:18:55Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE The aim of the present study was to evaluate rate of cyclin D1 expression and examine its relationship to clinicopathological factors and impact on prognosis in breast cancer patients. METHODS Total of 85 estrogen receptor (ER)-positive breast cancer patients were included. Expression of cyclin D1, ER, progesterone receptor (PR), and Ki-67 were determined using immunohistochemistry evaluation. RESULTS Patients' median age was 49 years (range: 27-83 years) and cyclin D1 was positive in 90.5% of the patients. Cyclin D1 expression was positively correlated with rate of ER positivity and Ki-67 expression (r=0.4; p<0.0001 and r=0.3; p=0.001, respectively). Five-year disease-free and overall survival (OS) rates were not different between patients with or without cyclin D1 expression (81% vs 79% and 93% vs 87%; p=0.8 and 0.4, respectively). High modified Bloom-Richardson grade (p=0.04), high nuclear grade (p=0.021), and PR negativity (p=0.011) were found to be poor prognostic factors for OS rate in univariate analysis. CONCLUSION In this study, cyclin D1 was not found to be prognostic factor; however, it is correlated with ER positivity and Ki-67 expression in breast cancer patients.en_US
dc.identifier.doi10.5505/tjo.2017.1386
dc.identifier.endpage13en_US
dc.identifier.issn1300-7467
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2017.1386
dc.identifier.urihttps://hdl.handle.net/11454/32650
dc.identifier.volume32en_US
dc.identifier.wosWOS:000424784400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.subjectcyclin D1en_US
dc.subjectprognostic factorsen_US
dc.titleExpression of Cyclin D1 and Its Relationship to Hormone Receptors and Survival in Breast Canceren_US
dc.typeArticleen_US

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