Effects of blood products on nosocomial infections in liver transplant recipients

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dc.contributor.authorOzkardesler S.
dc.contributor.authorAvkan-Oguz V.
dc.contributor.authorAkan M.
dc.contributor.authorUnek T.
dc.contributor.authorOzbilgin M.
dc.contributor.authorMeseri R.
dc.contributor.authorCimen M.
dc.contributor.authorKarademir S.
dc.date.accessioned2019-10-27T08:23:05Z
dc.date.available2019-10-27T08:23:05Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Infection is the most severe complication after an organ transplant. Blood cell transfusion is an independent risk factor for adverse events, including infection in the recipient. This study sought to evaluate the effect of blood product transfusions on nosocomial infections in liver transplant patients. Materials and Methods: Patients who underwent a liver transplant at our hospital between 2003 and 2010 were recruited for this study. Exclusion criteria were incomplete records, patients who were hospitalized for more than 48 hours during the 4 weeks before transplant, and pediatric transplants. Incidence of nosocomial infections, which were defined as infections occurring within 30 days after transplant was the primary endpoint. Results: The incidence of nosocomial infections was 28.7%. The number of transfusions of packed red blood cells and fresh frozen plasma was significantly higher in patients with nosocomial infection compared with patients without nosocomial infection (P =.018 and P =.039). Blood products dose-dependently contributed to nosocomial infections. Transfusions of ? 7.5 units of red blood cells (odds ratio: 2.8) or ? 12.5 units of fresh frozen plasma (odds ratio: 3.27) were associated with nosocomial infections (P =.042 and P =.015). The infection-related mortality rate was 10.3%. Conclusions: Blood product transfusions are associated with an increased rate of nosocomial infections, which contributes to higher morbidity and mortality. © Başkent University 2013. Printed in Turkey. All Rights Reserved.en_US
dc.identifier.doi10.6002/ect.2012.0286en_US
dc.identifier.endpage536en_US
dc.identifier.issn1304-0855
dc.identifier.issue6en_US
dc.identifier.pmid23901878en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2012.0286
dc.identifier.urihttps://hdl.handle.net/11454/26368
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood productsen_US
dc.subjectInfectionen_US
dc.subjectLiver transplanten_US
dc.subjectPlasmaen_US
dc.subjectRed blood cellsen_US
dc.titleEffects of blood products on nosocomial infections in liver transplant recipientsen_US
dc.typeArticleen_US

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