CRISPR Technology in Gene-Editing-Based Detection and Treatment of SARS-CoV-2

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dc.authorscopusid57216431373
dc.authorscopusid55565668500
dc.authorscopusid57193747336
dc.authorscopusid57193747964
dc.authorscopusid57212299393
dc.authorscopusid57218308284
dc.authorwosidBiray Avcı, Cigir/GWV-1665-2022
dc.contributor.authorShademan, Behrouz
dc.contributor.authorNourazarian, Alireza
dc.contributor.authorHajazimian, Saba
dc.contributor.authorIsazadeh, Alireza
dc.contributor.authorBiray Avci, Cigir
dc.contributor.authorOskouee, Mahin Ahangar
dc.date.accessioned2023-01-12T20:15:24Z
dc.date.available2023-01-12T20:15:24Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractOutbreak and rapid spread of coronavirus disease (COVID-19) caused by coronavirus acute respiratory syndrome (SARS-CoV-2) caused severe acute respiratory syndrome (SARS-CoV-2) that started in Wuhan, and has become a global problem because of the high rate of human-to-human transmission and severe respiratory infections. Because of high prevalence of SARS-CoV-2, which threatens many people worldwide, rapid diagnosis and simple treatment are needed. Genome editing is a nucleic acid-based approach to altering the genome by artificially changes in genetic information and induce irreversible changes in the function of target gene. Clustered, regularly interspaced short palindromic repeats (CRISPR/Cas) could be a practical and straightforward approach to this disease. CRISPR/Cas system contains Cas protein, which is controlled by a small RNA molecule to create a double-stranded DNA gap. Evidence suggested that CRISPR/Cas was also usable for diagnosis and treatment of SARS-CoV-2 infection. In this review study, we discoursed on application of CRISPR technology in detection and treatment of SARS-CoV-2 infection. Another aspect of this study was to introduce potential future problems in use of CRISPR/Cas technology.en_US
dc.identifier.doi10.3389/fmolb.2021.772788
dc.identifier.issn2296-889X
dc.identifier.pmid35087864en_US
dc.identifier.scopus2-s2.0-85123444427en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fmolb.2021.772788
dc.identifier.urihttps://hdl.handle.net/11454/78462
dc.identifier.volume8en_US
dc.identifier.wosWOS:000748055300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Molecular Biosciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcoronavirusesen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCRISPRen_US
dc.subjectCas9en_US
dc.subjectgene editingen_US
dc.subjectACE-2 receptorsen_US
dc.subjectSpike Proteinen_US
dc.subjectSars-Coven_US
dc.subjectCoronavirusen_US
dc.subjectReceptoren_US
dc.subjectHosten_US
dc.subjectTargeten_US
dc.subjectIdentificationen_US
dc.subjectArchitectureen_US
dc.subjectReplicationen_US
dc.subjectDiagnosticsen_US
dc.titleCRISPR Technology in Gene-Editing-Based Detection and Treatment of SARS-CoV-2en_US
dc.typeReviewen_US

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