Characterization and Antimicrobial Activity of Novel Hazelnut Oil Microemulsion Loaded with Mitomycin C

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dc.contributor.authorKotmakci, Mustafa
dc.contributor.authorOzturk, Ismail
dc.contributor.authorKantarci, Gulten
dc.contributor.authorErmertcan, Safak
dc.date.accessioned2019-10-27T22:29:51Z
dc.date.available2019-10-27T22:29:51Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to prepare and characterize a mitomycin C-loaded hazelnut oil microemulsion, and to examine its antimicrobial activity on bacteria and fungi. Microemulsions were prepared by titration of the oil-surfactant mixture with the water phase, and characterized for their physicochemical properties. In vitro release study was carried out by dialysis technique. In vitro antimicrobial activity on bacteria and fungi was examined by microdilution method and disc diffusion test. The hazelnut oil microemulsion has a droplet size of 27.6 nm which increased to 52.0 nm after mitomycin C loading. Mitomycin C-hazelnut oil microemulsion showed more effective bactericidal activity on P. aeruginosa, B. subtilis and S. aureus as compared with mitomycin C-solution. In conclusion, our novel microemulsion may be a promising carrier system for mitomycin C to increase its therapeutic effect on the infections originated from P. aeruginosa, S. aureus and B. subtilis.en_US
dc.identifier.endpage536en_US
dc.identifier.issn0326-2383
dc.identifier.issn0326-2383en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://hdl.handle.net/11454/51169
dc.identifier.volume34en_US
dc.identifier.wosWOS:000353952100015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial activityen_US
dc.subjecthazelnut oilen_US
dc.subjectmicroemulsionen_US
dc.subjectmitomycin cen_US
dc.subjectsoybean oilen_US
dc.titleCharacterization and Antimicrobial Activity of Novel Hazelnut Oil Microemulsion Loaded with Mitomycin Cen_US
dc.typeArticleen_US

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