Characterization and Antimicrobial Activity of Novel Hazelnut Oil Microemulsion Loaded with Mitomycin C
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Colegio Farmaceuticos Provincia De Buenos Aires
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to prepare and characterize a mitomycin C-loaded hazelnut oil microemulsion, and to examine its antimicrobial activity on bacteria and fungi. Microemulsions were prepared by titration of the oil-surfactant mixture with the water phase, and characterized for their physicochemical properties. In vitro release study was carried out by dialysis technique. In vitro antimicrobial activity on bacteria and fungi was examined by microdilution method and disc diffusion test. The hazelnut oil microemulsion has a droplet size of 27.6 nm which increased to 52.0 nm after mitomycin C loading. Mitomycin C-hazelnut oil microemulsion showed more effective bactericidal activity on P. aeruginosa, B. subtilis and S. aureus as compared with mitomycin C-solution. In conclusion, our novel microemulsion may be a promising carrier system for mitomycin C to increase its therapeutic effect on the infections originated from P. aeruginosa, S. aureus and B. subtilis.
Açıklama
Anahtar Kelimeler
antimicrobial activity, hazelnut oil, microemulsion, mitomycin c, soybean oil
Kaynak
Latin American Journal of Pharmacy
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
34
Sayı
3
