Association of macrophage migration inhibitory factor gene-173 G/C polymorphism with prognosis in turkish children with juvenile rheumatoid arthritis

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dc.contributor.authorBerdeli, G.
dc.contributor.authorOezyuerek, Arif Ruhi
dc.contributor.authorUelger, Zuelal
dc.contributor.authorGuerses, Dolunay
dc.contributor.authorLevent, Ertuerk
dc.contributor.authorSalar, Koray
dc.contributor.authorGuerpinar, Ali Rahmi
dc.date.accessioned2019-10-27T19:18:31Z
dc.date.available2019-10-27T19:18:31Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractThe objectives of this study were to determine genotypic and allelic frequencies of macrophage migration inhibitory factor (MIF) gene -173 G/C polymorphism in patients with juvenile rheumatoid arthritis (JRA) and to evaluate the association of the MIF -173 C allele with the outcome of JRA. Genomic DNA was collected from 67 JRA patients and 153 healthy individuals. To evaluate the association of the MIF -173 polymorphism with the outcome, we analyzed the data concerning the treatment regimen, duration of glucocorticoid treatment, score on the childhood health assessment questionnaire (C-HAQ) and the number of joints with active arthritis. Nonsignificant differences were observed between the study and control groups in the distribution of genotype and allele frequencies of the MIF gene -173 G/C polymorphism. In JRA patients, carrying a MIF -173 C allele, the number of disease modifying antirheumatic drugs required for the treatment was more, the duration of glucocorticoid treatment was significantly longer, and at the last visits the C-HAQ scores and the number of joints with active arthritis were significantly higher. MIF gene -173 C allele frequency did not differ between the controls and JRA patients. MIF -173 C allele did not confer increased susceptibility to JRA in our study group. Carriage of the MIF -173 C allele was found to be a strong predictor of poor outcome in all types of JRA.en_US
dc.identifier.doi10.1007/s00296-005-0062-7en_US
dc.identifier.endpage731en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue8en_US
dc.identifier.pmid16220288en_US
dc.identifier.startpage726en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0062-7
dc.identifier.urihttps://hdl.handle.net/11454/38604
dc.identifier.volume26en_US
dc.identifier.wosWOS:000237468100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectjuvenile rheumatoid arthritisen_US
dc.subjectmacrophage migration inhibitory factor geneen_US
dc.subjectpolymorphismen_US
dc.subjectallele frequencyen_US
dc.subjectprognosisen_US
dc.titleAssociation of macrophage migration inhibitory factor gene-173 G/C polymorphism with prognosis in turkish children with juvenile rheumatoid arthritisen_US
dc.typeArticleen_US

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