The diagnostic utility of scintigraphy in esophageal burn: a rat model

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dc.contributor.authorCiftci, Oznur Dilek
dc.contributor.authorGul, Serdar Savas
dc.contributor.authorAciksari, Kurtulus
dc.contributor.authorMaman, Adem
dc.contributor.authorCavusoglu, Turker
dc.contributor.authorBademci, Refik
dc.contributor.authorTaskiran, Dilek
dc.contributor.authorErbas, Oytun
dc.date.accessioned2019-10-27T23:11:41Z
dc.date.available2019-10-27T23:11:41Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries. The present study was conducted to evaluate the diagnostic utility of technetium-99m-pyrophosphate (Tc-99m-PYP) scintigraphy in the early stage of esophageal burns by using different concentrations of sodium hydroxide (NaOH) in an experimental rat model. Materials and methods: Twenty-eight male Spraguee-Dawley rats, weighing 200-250 g, were used in the study. Esophageal burn model was created in 21 rats by gastrically infusion of various concentrations of NaOH. The rats were divided randomly into three groups: mildburn group (n = 7) received 15% NaOH, moderate-burn group (n = 7) received 30% NaOH and severe-burn group (n = 7) received 45% NaOH. Seven rats were identified as control group and received normal saline. Three hours after burn injury, 1-mCi Tc-99m-PYP was administered through tail vein. Two hours after Tc-99m-PYP administration, static imaging with gamma camera was performed. Then, histopathologic assessment of esophageal samples was achieved properly. Results: All NaOH-applied groups (mild, moderate, and severe) showed a significant higher uptake ratio when compared to control group (P < 0.005). NaOH-applied groups displayed important histologic alterations such as mucosal disintegration, edema, inflammation, and stromal damage when compared to control group. Pearson correlation analysis revealed a significant correlation between the Tc-99m-PYP uptake ratio and histologic score (P < 0.0005). Conclusions: The scintigraphic imaging may provide advantages in the early stage of esophageal burns in some patients whom endoscopic procedure is contraindicated because of its high risk of complications such as bleeding and perforation. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2015.09.006en_US
dc.identifier.endpage500en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid26428089en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage495en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2015.09.006
dc.identifier.urihttps://hdl.handle.net/11454/53115
dc.identifier.volume200en_US
dc.identifier.wosWOS:000366841500012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic injuryen_US
dc.subjectTechnesium 99m scintigraphyen_US
dc.subjectCaustic substanceen_US
dc.subjectEsophagitisen_US
dc.subjectEndoscopyen_US
dc.titleThe diagnostic utility of scintigraphy in esophageal burn: a rat modelen_US
dc.typeArticleen_US

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