Clinical Approach to Ocular Cicatricial Pemphigoid

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dc.authorscopusid57225957320
dc.authorscopusid57361433900
dc.authorscopusid23989747000
dc.authorscopusid55344634000
dc.authorscopusid6602843026
dc.authorscopusid7003943383
dc.authorscopusid6603693120
dc.contributor.authorÇiftçi, M.D.
dc.contributor.authorKorkmaz, İ.
dc.contributor.authorPalamar, M.
dc.contributor.authorYaman, B.
dc.contributor.authorEğrilmez, S.
dc.contributor.authorYağcı, A.
dc.contributor.authorAkalın, T.
dc.date.accessioned2024-08-25T18:48:42Z
dc.date.available2024-08-25T18:48:42Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To evaluate the demographic data, ocular and systemic findings, clinical management, and outcomes of patients with ocular cicatricial pemphigoid (OCP). Materials and Methods: The medical records of 11 patients diagnosed as having OCP in the ophthalmology department of Ege University between 2008 and 2021 were evaluated retrospectively. Results: The patients' mean follow-up time was 14±5.76 months. All eyes (100%) had conjunctival involvement and 18 (81.81%) had corneal involvement. According to the Tauber staging system, 7 (31.81%), 8 (36.36%), and 7 (31.81%) of the eyes were stage 2, 3, and 4, respectively. The diagnosis was confirmed in 6 (66.66%) of 9 patients who underwent biopsy. Amniotic membrane transplantation was performed in 7 eyes, entropion surgery in 2 eyes, and electrocauterization for trichiasis in 5 eyes. Systemic involvement was observed in 45.45% (5/11) of patients, most commonly oral mucosal involvement (18.18%). Review of medical records showed that alkylating agents, steroids, and dapsone were used in patients treated before 2020. Mycophenolate mofetil was preferred to be used in combination with corticosteroids. Although treatment responses before mycophenolate mofetil usage could not be evaluated well because of loss to follow-up, 4 (66.66%) of 6 patients who received steroid treatment combined with mycophenolate mofetil showed partial or complete clinical remission. No serious side effects and drug withdrawal were observed. Conclusion: OCP is a sight-threatening autoimmune disease that affects older adults. Although positive biopsy results are valuable for diagnosis, negative results do not exclude the diagnosis. The main treatment is systemic immunosuppressives. Disease activity can be suppressed, especially with early initiation of drug therapy. These patients require a multidisciplinary approach. Especially in the presence of isolated ocular findings, ophthalmologists should be able to make the decision to start immunosuppressive treatment, and systemic treatment should not be delayed. ©Copyright 2023 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House.en_US
dc.identifier.doi10.4274/tjo.galenos.2022.34683
dc.identifier.endpage84en_US
dc.identifier.issn2149-8709
dc.identifier.issue2en_US
dc.identifier.pmid37089009en_US
dc.identifier.scopus2-s2.0-85153803787en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.galenos.2022.34683
dc.identifier.urihttps://hdl.handle.net/11454/102382
dc.identifier.volume53en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofTurkish journal of ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcicatricial conjunctivitisen_US
dc.subjectimmunofluorescenceen_US
dc.subjectmycophenolate mofetilen_US
dc.subjectOcular cicatricial pemphigoiden_US
dc.subjectimmunosuppressive agenten_US
dc.subjectmycophenolic aciden_US
dc.subjectageden_US
dc.subjectcomplicationen_US
dc.subjectconjunctivaen_US
dc.subjecthumanen_US
dc.subjectmucous membrane pemphigoiden_US
dc.subjectpathologyen_US
dc.subjectretrospective studyen_US
dc.subjectAgeden_US
dc.subjectConjunctivaen_US
dc.subjectHumansen_US
dc.subjectImmunosuppressive Agentsen_US
dc.subjectMycophenolic Aciden_US
dc.subjectPemphigoid, Benign Mucous Membraneen_US
dc.subjectRetrospective Studiesen_US
dc.titleClinical Approach to Ocular Cicatricial Pemphigoiden_US
dc.typeArticleen_US

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