GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-optimized GRA1 DNA vaccine was slightly better than wild type GRA1 DNA vaccine. © 2006 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Adjuvanted recombinant protein vaccination, Codon-optimization, DNA vaccination, GRA1, Toxoplasma gondii
Kaynak
Vaccine
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
25
Sayı
10
