The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children

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dc.contributor.authorKurugol, Zafer
dc.contributor.authorAkilli, Munevver
dc.contributor.authorBayram, Nuri
dc.contributor.authorKoturoglu, Guldane
dc.date.accessioned2019-10-27T19:17:08Z
dc.date.available2019-10-27T19:17:08Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: To determine the efficacy of prophylactic administration of zinc sulphate in reducing the occurrence of the common cold in children, and to evaluate the efficacy of zinc sulphate in reducing the duration and severity of cold symptoms. Methods: A total of 200 healthy children were randomly assigned to receive oral zinc sulphate ( zinc group, n = 100) or placebo ( placebo group, n = 100). Zinc sulphate ( 15 mg of zinc) or placebo syrup were administered for prophylaxis once daily during a 7-mo study period. The dose was increased to two times per day ( 30 mg of zinc) at the onset of cold, until symptoms resolved. Results: The mean number of colds in the zinc group was significantly less than in the placebo group ( 1.2 vs 1.7 colds per child; p = 0.003). The mean cold-related school absence was 0.9 d per child in the zinc group versus 1.3 d in the placebo group ( p = 0.04). Compared to the placebo group, the zinc group had shorter mean duration of cold symptoms and decreased total severity scores for cold symptoms ( p < 0.0001). Adverse effects were mild and similar in both groups. Conclusion: Zinc sulphate appears to be an easily administered, safe and well-tolerated alternative for the prevention and treatment of the common cold in children.en_US
dc.identifier.doi10.1080/08035250600603024en_US
dc.identifier.endpage1181en_US
dc.identifier.issn0803-5253
dc.identifier.issn1651-2227
dc.identifier.issue10en_US
dc.identifier.pmid16982486en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1175en_US
dc.identifier.urihttps://doi.org/10.1080/08035250600603024
dc.identifier.urihttps://hdl.handle.net/11454/38306
dc.identifier.volume95en_US
dc.identifier.wosWOS:000240562000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Paediatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectprophylaxisen_US
dc.subjectupper respiratory infectionsen_US
dc.subjectzincen_US
dc.titleThe prophylactic and therapeutic effectiveness of zinc sulphate on common cold in childrenen_US
dc.typeArticleen_US

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