Comparison of the sedative, anxiolytic, hemodynamic and amnesic effects of clonidine and lorazepam premedication with placebo [ORAL KLONIDIN VE LORAZEPAM PREMEDIKASYONUNUN SEDATIF, ANKSIYOLITIK, HEMODINAMIK VE AMNEZIK ETKILERININ PLASEBO ILE KARSILASTIRILMASI]

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dc.contributor.authorUyar M.
dc.contributor.authorUyar M.
dc.contributor.authorMert S.
dc.contributor.authorOzyar B.
dc.contributor.authorBilge S.
dc.contributor.authorUgur G.
dc.contributor.authorGokce B.
dc.date.accessioned2019-10-27T00:32:45Z
dc.date.available2019-10-27T00:32:45Z
dc.date.issued1996
dc.departmentEge Üniversitesien_US
dc.description.abstractThe effects of 0.15 mg clonidine and 2 mg lorazepam premedication on sedation, anxiety, hemodynamic response to induction and laryngoscopy, IV anesthetic close and recovery were compared with placebo in 45 ASA I-II patients undergoing urological surgery under general anesthesia. Sedation was assessed by 3-point scale, anxiety by Lineer Anxiety Score (0-100 mm) and State-Trait Anxiety Inventory, induction duality by 4-point scale and amnesia by whether the patient remembered 5 different events 3 hours after the operation. Clonidine and lorazepam produced more sedation and less anxiety than placebo (p<0.05). Hemodynamic response to intubation was not prevented in all groups. Quality of induction was better and propofol dose was lower in clonidine group (p<0.05). Amnesia was more marked in lorazepam group (p<0.05). Time to eye opening, orientation and first analgesic request was not different among the three groups. Oral clonidine premedication was found to be a good alternative to benzodiazepines for routine use with regard to its effects on sedation, anxiolysis, induction quality and induction dose of propofol.en_US
dc.identifier.endpage171en_US
dc.identifier.issn1016-5150
dc.identifier.issn1016-5150en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://hdl.handle.net/11454/23884
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClonidineen_US
dc.subjectLorazepamen_US
dc.subjectPremedicationen_US
dc.titleComparison of the sedative, anxiolytic, hemodynamic and amnesic effects of clonidine and lorazepam premedication with placebo [ORAL KLONIDIN VE LORAZEPAM PREMEDIKASYONUNUN SEDATIF, ANKSIYOLITIK, HEMODINAMIK VE AMNEZIK ETKILERININ PLASEBO ILE KARSILASTIRILMASI]en_US
dc.typeArticleen_US

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