Comparison of the sedative, anxiolytic, hemodynamic and amnesic effects of clonidine and lorazepam premedication with placebo [ORAL KLONIDIN VE LORAZEPAM PREMEDIKASYONUNUN SEDATIF, ANKSIYOLITIK, HEMODINAMIK VE AMNEZIK ETKILERININ PLASEBO ILE KARSILASTIRILMASI]
Küçük Resim Yok
Tarih
1996
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effects of 0.15 mg clonidine and 2 mg lorazepam premedication on sedation, anxiety, hemodynamic response to induction and laryngoscopy, IV anesthetic close and recovery were compared with placebo in 45 ASA I-II patients undergoing urological surgery under general anesthesia. Sedation was assessed by 3-point scale, anxiety by Lineer Anxiety Score (0-100 mm) and State-Trait Anxiety Inventory, induction duality by 4-point scale and amnesia by whether the patient remembered 5 different events 3 hours after the operation. Clonidine and lorazepam produced more sedation and less anxiety than placebo (p<0.05). Hemodynamic response to intubation was not prevented in all groups. Quality of induction was better and propofol dose was lower in clonidine group (p<0.05). Amnesia was more marked in lorazepam group (p<0.05). Time to eye opening, orientation and first analgesic request was not different among the three groups. Oral clonidine premedication was found to be a good alternative to benzodiazepines for routine use with regard to its effects on sedation, anxiolysis, induction quality and induction dose of propofol.
Açıklama
Anahtar Kelimeler
Clonidine, Lorazepam, Premedication
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
24
Sayı
4
