Analysis of factors affecting repeat microdissection testicular sperm extraction outcomes in infertile men

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dc.contributor.authorKizilay, Fuat
dc.contributor.authorSemerci, Bulent
dc.contributor.authorSimsir, Adnan
dc.contributor.authorKalemci, Serdar
dc.contributor.authorAltay, Baris
dc.date.accessioned2020-12-01T12:06:34Z
dc.date.available2020-12-01T12:06:34Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: There is no clear consensus on which patients and how many of microscopic testicular sperm extraction (mTESE) procedures will be successful. in this study, we aimed to evaluate the sperm retrieval rates and factors affecting these rates in men who underwent repeat mTESEs. Material and methods: A total of 346 patients who underwent mTESE for sperm retrieval were included in the study. Patients were divided into groups according to the number of mTESE operations. Patients' karyotype, follicle-stimulating hormone (FSH) and testosterone levels, varicocele presence, and testis volumes were recorded from patient files. the sperm retrieval rates were compared between groups, and predicting factors for successful sperm retrieval were evaluated. Results: Microscopic TESE was applied for the first time in 244 patients, 1-2 times in 73 patients, and 3-4 times in 29 patients. There was a significant difference between groups in preoperative FSH values and postoperative testicular histopathology (p=0.004 and p<0.001). the sperm retrieval rate in the group of patients who had not undergone previous TESE was higher than the group of patients that had undergone TESE for 1-2 times and 3-4 times (p=0.028). in addition, testicular volume, histology, karyotype, and Y-chromosome microdeletion were predicting factors for successful sperm retrieval (p=0.011, p=0.039, p=0.002, and p<0.001, respectively). Conclusion: Our results confirm the necessity for repeat mTESE operations to be performed by experienced surgeons in reference centers to optimize the chance of reduced sperm retrieval rates with recurrent biopsies.en_US
dc.identifier.doi10.5152/tud.2019.76009en_US
dc.identifier.endpage6en_US
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.pmid30817282en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5152/tud.2019.76009
dc.identifier.urihttps://hdl.handle.net/11454/63245
dc.identifier.volume45en_US
dc.identifier.wosWOS:000502637300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfertilityen_US
dc.subjectmicroscopic testicular sperm extractionen_US
dc.subjectnon-obstructive azoospermiaen_US
dc.subjectsperm retrievalen_US
dc.titleAnalysis of factors affecting repeat microdissection testicular sperm extraction outcomes in infertile menen_US
dc.typeArticleen_US

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