Immunological methods for diagnosis and monitoring of IgE-mediated allergy caused by industrial sensitizing agents (IMExAllergy)

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dc.contributor.authorBaur, Xaver
dc.contributor.authorAkdis, Cezmi A.
dc.contributor.authorBudnik, Lygia Therese
dc.contributor.authorCruz, Maria Jesus
dc.contributor.authorFischer, Axel
dc.contributor.authorFoerster-Ruhrmann, Ulrike
dc.contributor.authorGoeen, Thomas
dc.contributor.authorGoksel, Ozlem
dc.contributor.authorHeutelbeck, Astrid R.
dc.contributor.authorJones, Meinir
dc.contributor.authorLux, Harald
dc.contributor.authorMaestrelli, Piero
dc.contributor.authorMunoz, Xavier
dc.contributor.authorNemery, Benoit
dc.contributor.authorSchluenssen, Vivi
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorTraidl-Hoffmann, Claudia
dc.contributor.authorSiegel, Paul
dc.date.accessioned2019-10-27T09:43:30Z
dc.date.available2019-10-27T09:43:30Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIndustrial sensitizing agents (allergens) in living and working environments play an important role in eliciting type 1 allergic disorders including asthma and allergic rhinitis. Successful management of allergic diseases necessitates identifying their specific causes (ie, identify the causative agent(s) and the route of contact to allergen: airborne, or skin contact) to avoid further exposure. Identification of sensitization by a sensitive and validated measurement of specific IgE is an important step in the diagnosis. However, only a limited number of environmental and occupational allergens are available on the market for use in sIgE testing. Accordingly, specific in-house testing by individual diagnostic and laboratory centers is often required. Currently, different immunological tests are in use at various diagnostic centers that often produce considerably divergent results, mostly due to lack of standardized allergen preparation and standardized procedures as well as inadequate quality control. Our review and meta-analysis exhibited satisfactory performance of sIgE detection test for most high molecular weight (HMW) allergens with a pooled sensitivity of 0.74 and specificity of 0.71. However, for low molecular weight (LMW) allergens, pooled sensitivity is generally lower (0.28) and specificity higher (0.89) than for HMW tests. Major recommendations based on the presented data include diagnostic use of sIgE to HMW allergens. A negative sIgE result for LMW agents does not exclude sensitization. In addition, the requirements for full transparency of the content of allergen preparations with details on standardization and quality control are underlined. Development of standard operating procedures for in-house sIgE assays, and clinical validation, centralized quality control and audits are emphasized. There is also a need for specialized laboratories to provide a custom service for the development of tests for the measurement of putative novel occupational allergens that are not commercially available.en_US
dc.description.sponsorshipEU-COST-Action DiMoPEx [CA-15129]; EU Framework Program Horizon 2020en_US
dc.description.sponsorshipAll authors are salaried staff members of their respective institutions (XB is retired University Professor and chair for occupational medicine, University of Hamburg). The guideline was prepared with financial support from the EU-COST-Action (CA-15129, DiMoPEx), which is supported by the EU Framework Program Horizon 2020.en_US
dc.identifier.doi10.1111/all.13809en_US
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.pmid30953599en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/all.13809
dc.identifier.urihttps://hdl.handle.net/11454/28877
dc.identifier.wosWOS:000473592800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAllergyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasthmaen_US
dc.subjectIgEen_US
dc.subjectoccupational allergiesen_US
dc.subjectrhinitisen_US
dc.subjecturticariaen_US
dc.titleImmunological methods for diagnosis and monitoring of IgE-mediated allergy caused by industrial sensitizing agents (IMExAllergy)en_US
dc.typeReview Articleen_US

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