Protein and Gene Delivery Systems for Neurodegenerative Disorders: Where Do We Stand Today?

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dc.authoridokur, mehmet evren/0000-0001-7706-6452
dc.authoridOZGENC, EMRE/0000-0002-7586-8520
dc.authoridÇağlar, Emre Şefik/0000-0003-2010-4918
dc.authoridUstundag Okur, Neslihan/0000-0002-3210-3747
dc.authoridSiafaka, Panoraia I./0000-0001-7256-3230
dc.authoridParlar Koprulu, Rabia Edibe/0000-0003-0052-3648
dc.authoridDilsiz, Pelin/0000-0001-9192-5014
dc.authorscopusid55200365700
dc.authorscopusid57194101406
dc.authorscopusid57962792000
dc.authorscopusid57038535000
dc.authorscopusid56662137100
dc.authorscopusid42361184800
dc.authorscopusid57226007713
dc.authorwosidokur, mehmet evren/AAI-1962-2019
dc.authorwosidOZGENC, EMRE/AGN-7731-2022
dc.authorwosidÇağlar, Emre Şefik/AAD-8879-2020
dc.contributor.authorSiafaka, Panoraia, I
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorErim, Pelin Dilsiz
dc.contributor.authorCaglar, Emre Sefik
dc.contributor.authorOzgenc, Emre
dc.contributor.authorGundogdu, Evren
dc.contributor.authorKoprulu, Rabia Edibe Parlar
dc.date.accessioned2023-01-12T20:15:45Z
dc.date.available2023-01-12T20:15:45Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractIt has been estimated that every year, millions of people are affected by neurodegenerative disorders, which complicate their lives and their caregivers' lives. To date, there has not been an approved pharmacological approach to provide the complete treatment of neurodegenerative disorders. The only available drugs may only relieve the symptoms or slow down the progression of the disease. The absence of any treatment is quite rational given that neurodegeneration occurs by the progressive loss of the function or structure of the nerve cells of the brain or the peripheral nervous system, which eventually leads to their death either by apoptosis or necrotic cell death. According to a recent study, even though adult brain cells are injured, they can revert to an embryonic state, which may help to restore their function. These interesting findings might open a new path for the development of more efficient therapeutic strategies to combat devastating neurodegenerative disorders. Gene and protein therapies have emerged as a rapidly growing field for various disorders, especially neurodegenerative diseases. Despite these promising therapies, the complete treatment of neurodegenerative disorders has not yet been achieved. Therefore, the aim of this review is to address the most up-to-date data for neurodegenerative diseases, but most importantly, to summarize the available delivery systems incorporating proteins, peptides, and genes that can potentially target such diseases and pass into the blood-brain barrier. The authors highlight the advancements, at present, on delivery based on the carrier, i.e., lipid, polymeric, and inorganic, as well as the recent studies on radiopharmaceutical theranostics.en_US
dc.identifier.doi10.3390/pharmaceutics14112425
dc.identifier.issn1999-4923
dc.identifier.issue11en_US
dc.identifier.pmid36365243en_US
dc.identifier.scopus2-s2.0-85141792742en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14112425
dc.identifier.urihttps://hdl.handle.net/11454/78562
dc.identifier.volume14en_US
dc.identifier.wosWOS:000881522400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneurodegenerative diseasesen_US
dc.subjectgenesen_US
dc.subjectproteinen_US
dc.subjectmonoclonal antibodiesen_US
dc.subjectpeptidesen_US
dc.subjecttheranosticsen_US
dc.subjectDual-Functional Nanoparticlesen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectNerve Growth-Factoren_US
dc.subjectIn-Vivo Evaluationen_US
dc.subjectTotal-Body Peten_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectDrug-Deliveryen_US
dc.subjectIntranasal Deliveryen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectCognitive Functionen_US
dc.titleProtein and Gene Delivery Systems for Neurodegenerative Disorders: Where Do We Stand Today?en_US
dc.typeReviewen_US

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