The healing effects of Hyperium perforatum (St. John’s Wort) on experimental alkaline corrosive eosephageal and stomach burns

Basit Öğe Kaydı
dc.contributor.authorUyanıkgil, Emel Öykü Çetin
dc.contributor.authorKarabey, Fatih
dc.contributor.authorGökçe, Burak
dc.contributor.authorGüvenç, Erkan
dc.contributor.authorKıyan, Selahattin
dc.contributor.authorÇavuşoğlu, Türker
dc.contributor.authorUyanıkgil, Yiğit
dc.date.accessioned2023-01-12T20:27:19Z
dc.date.available2023-01-12T20:27:19Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractBACKGROUND:The most frequent etiologic cause is alkaline substances. We investigated the protective effects of the plant St. John ‘s Wort (Hypericum perforatum).METHODS:We included 42 Wistar albino rats weighing between 200–300 grams and divided into six groups as Group 1: Con-trol, Group 2: Burn+Saline (BS), Group 3: Burn+St. John’s Wort (BSJW), Group 4: Burn+Plasebo (BP), Group 5: St. John’s Wort (SJW), Group 6: Placebo (P). After 15 days of treatment, esophagus, stomach and liver tissue samples were derived by dissection for histopathologic and biochemical markers. The cytotoxic effects of formulation on fibroblasts is evaluated in vitro on human dermoblast fibroblast line (HDFa, Gibco Invitrogen cell culture, C-013-5C).RESULTS:The weight of the rats increased in Group 1, 3, 4, 6, decreased in Group 2 and did not change in Group 5. In the BSJW group, submucosal collagen accumulation, muscularis mucosa damage, tunica muscularis damage and collagen accumulation in esopha-gus were similar to the control group but lesser than BS and placebo group. In the stomach, mucosal damage, gastric gland dilatation, submucosal polymorphonuclear infiltration were similar to the control group and lesser than the BS group. The lethal concentration of SJW was 2.58 gr/mL.CONCLUSION:SJW substrate is effective in protecting the esophagus and stomach in mild to moderate alcali corrosive burns in the subacute period. We should keep in mind the protective effects of STW substrate in alkaline corrosive burns of the gastrointestinal system.en_US
dc.identifier.doi10.14744/tjtes.2019.93428
dc.identifier.endpage383en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue3en_US
dc.identifier.startpage373en_US
dc.identifier.trdizinid423799en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2019.93428
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/423799
dc.identifier.urihttps://hdl.handle.net/11454/80239
dc.identifier.volume26en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe healing effects of Hyperium perforatum (St. John’s Wort) on experimental alkaline corrosive eosephageal and stomach burnsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu